DMSO some additional comments/clarifications....
Willy A Verheulpen
waverheu at vub.ac.be
Fri Dec 3 03:27:46 EST 1993
In article <2dltqe$js1 at unix1.circ.gwu.edu> wilesm at unix1.circ.gwu.edu (Marc Wiles) writes:
>From: wilesm at unix1.circ.gwu.edu (Marc Wiles)
>Subject: DMSO some additional comments/clarifications....
>Message-ID: <2dltqe$js1 at unix1.circ.gwu.edu>
>Date: 2 Dec 93 13:30:22 GMT
>Organization: The George Washington University
>Xref: rc1 sci.bio:6294 sci.chem:7563 bionet.general:3304
>Per my comments on DMSO in terms of carcinogenesis, teratogenesis, etc.:
>Perhaps I should have been more specific. It is possible that any such
>activity attributed to DMSO is a function of the compounds ability to act
>as a carrier for almost anything. In many instances, substances that
>can't be solubilized in aqueous media are readily soluble in DMSO. It is
>a fantastic vehicle for solubilization. In part, that is the problem. As
>such any potentially carcinogenic agent is readily delivered by DMSO.
>However, it is also very likely that DMSO may indeed have carcinogenic
>properties. In biological systems, DMSO is used as a lipid/membrane
>modifying agent. It will easily alter membrane function, protein
>distribution, etc. As such, it is not surprising that the agent could
>cause genetic alterations at the cellular level (ie. via nuclear membrane
>modification). Also, it should be noted that in experimental settings,
>DMSO is actually used *because* of it's ability to transform cells, for
>example, as a differentiating agent for myeloblastoid cell types (U937
>cell lines) to force polymorphonuclear leukocyte-like cell type formation.
>In essence, some of the commentary I've heard is that DMSO is currently
>considered much as compounds like acetone used to be.....no real hazard.
>The reality has become somewhat different.
>Dr. Marc Wiles
>George Washington University Medical Center
I fully second these statements. We used DMSO in fairly large quantities
for preparing reagents in an Amino Acid analyser. I frankly hated it because
one tends to get 'over' sensitive to the product & even the vapors were
capable of giving you a nasty taste in the mouth even by just entering the
analysis room. Furthermore the product, as manufactured by an American
company, had a huge label saying that "...the toxic properties & bio hazard
of this product have not fully been investigated so utmost care in the
manipulation of the compound is recommended ..."
Well, having had a training in chemistry, that's surely enough to scare me
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