Looking for address of laboratories in genetic researches
danj at welchgate.welch.jhu.edu
Thu Jun 10 08:32:55 EST 1993
In article <1993Jun9.113343.2471 at clover.csata.it> martin at mvx36.csata.it writes:
> I am looking for the address (both e-mail nad smail) of laboratories
> in Europe and North America which performs test on human genes
> to identify possible sources of malformation in the progeny.
Let's see what gopher can do:
Point your gopher client at merlot.welch.jhu.edu and select the following:
--> 15. Searching For Biologists/
--> 2. Search for All Researchers funded by NIH <?>
Now search for:
genetic and disorder and mapping
And you'll get lots of entries - one of which is as follows:
NYGAARD, TORBJOERN G
COLUMBIA U/NY STATE PSYCH INST
710 WEST 168TH STREET
NEW YORK, NY 10032
PERFORMING ORGANIZATION: COLUMBIA UNIVERSITY NEW YORK
TITLE Molecular genetics of dopa-responsive dystonia
This project is focused on locating the gene for "dopa-responsive dystonia"
(DRD), an autosomal dominant disorder. This disorder is a distinct subset
of childhood-onset, idiopathic torsion dystonia (ITD), but has several
features that separate it from ITD. In some cases it may have features
suggestive of cerebral palsy, before clinical progression should allow
separation of the disorders. Analysis of two families suggests that adult
onset parkinsonism may be the clinical phenotype of gene carriers who do
not manifest dystonia in childhood. This finding may have clinical
relevance in some cases of hereditary parkinsonism.
We propose to do linkage analysis on "Family S," the largest known kindred
affected with DRD, to identify a chromosomal region linked to DRD. We will
then use saturation mapping with known markers in the region or develop new
markers by selective cloning methods to further delimit an obligate genetic
region (OGR) for the DRD gene. We can then test for genetic heterogeneity
with other smaller DRD families.
A physical map of the OGR will be constructed by techniques such as pulse
field gel electrophoresis and chromosome "walking." Coding sequences will
be identified by several cloning and hybridization strategies and
"candidate regions" compared in DNA between normal and affected individuals
in an attempt to identify the disease locus.
Identification of the gene for DRD may allow better understanding of the
biochemical defect in DRD. Improved diagnostic reliability in childhood
dystonic conditions and some forms of adult-onset parkinsonism should be
polymerase chain reaction
autosomal dominant trait
dystonia musculorum deformans
nucleic acid hybridization
nucleic acid sequence
human genetic material tag
Ok, now you have a snail mail address and a description of what they're
doing - lets try for an e-mail address.
--> 12. Phonebooks Around the World/
--> 2. Phonebooks in North America/
--> 19. Columbia University <CSO>
and search for -
And the answer is :-)
name: Torbjoern G Nygaard
email: nygaard at cuccfa.ccc.columbia.edu
phone: +1 212-305-5771
You will need to adjust your searches to fit what you're looking
for - if you have specific diseases in mind use them as search words etc.
If you've never heard of gopher, don't worry it's free and on the net,
write me a note if you'd like info on how to get started.
Best of luck,
danj at welchgate.welch.jhu.edu
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