INFO NEEDED: CAMs/Inflammatory Diseases

PandaGroup pandagroup at aol.com
Wed Aug 31 20:33:12 EST 1994


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I am currently preparing a study on  the  current  and  potential
applications  of  CELL  ADHESION  MOLECULES   (CAMs)   and   CAMs
inhibitors to the treatment of inflammatory disease.  I would  be
grateful to anyone knowledgable in the field if they would answer 
the following questionnaire.

You may return your responses to me via E-mail, or you can  print
out the questionnaire and send the answers back to me via fax  at
(619) 436-4341.

Thank you.

Dr. Kenneth G. Krul
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NAME:
TITLE:
INSTITUTION:
ADDRESS:



PHONE #:
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QUESTIONS TO  BE  ANSWERED  BY  STUDY  ON  APPLICATIONS  OF  CAMs
TECHNOLOGY TO INFLAMMATORY DISEASES

Scope
This study will concentrate on the predicted use of cell adhesion 
molecules in the treatment of inflammatory  diseases  to  include
the following:

Selectins
     E-Selectin
     P-Selectin
     L-Selectin
Integrins
     LFA-1, LFA-3
     MAC-1
     Alpha-4/Beta-1 (VLA-4)
     gpIIb/IIIa
     Alpha-5 (VLA-5)
     Alpha-6 (VLA-6)
     Beta-1 (VLA 1-6), Beta-2 (CD-18), Beta-3
     Alpha-4/Beta-7
     Alpha-E/Beta-7 73 
Immunoglobulin Superfamily
     ICAM-1, ICAM-2, ICAM-R
     VCAM-1
     PECAM
     ELAM-1
     MAD CAM-1   
Others
     CD44
====================

Application in Medical Practice

1.  Where is  CAMs  therapy  seen  as  holding  a  place  in  the
treatment of inflammatory diseases as it is currently practiced?  






2.   What  is  its  (CAMs  therapy)  current  use   in   treating
inflammatory diseases, if any?  






3.  What horizons are seen for its use over  the  next  5  to  15
years?  






4.  What are the most probable CAMs therapy products to initially 
emerge in practical applications and why?  






5.  In what ways will CAMs therapy be used as adjunctive  therapy
to conventional treatment?   73 






6.  In what ways might  CAMs  therapy  be  used  as  the  primary
therapy?  





====================

Disease Specific Applications

7.  Of the major inflammatory diseases,  which  are  the  primary
targets of CAMs therapy?  






8.  How will this change over the next 5 to 15 years?  






9.  What are the prospects for CAMs applications in:

    a.  Rheumatoid Arthritis?



    b.  Autoimmunity (SLE,  vitiligo,  Graves  disease,  multiple
sclerosis,etc.)?



    c.  Chronic viral infection?



    d.  Allograft management?



    e.  Chronic bacterial inflammation/sepsis?



    f.  Asthma



    g.  Psoriasi



    h.  ARDS



    i.  Reperfusion Injur



    j.  SIRS





====================

Product Assessment

10.  Which of the CAMs therapy technologies or approaches appears 
to  have  the  greatest  application  in  treating   inflammatory
diseases?






11.  Which are of secondary importance?  






12.  What characteristics, including side-effect risks, or  other
contraindications will hinder or promote the  market  development
of CAMs therapy in the treatment of inflammatory diseases?  






13.  What clinical trials are under way involving the CAMs in the 
treatment of inflammatory diseases?  






14.  What are the results to date?  






15.  What opinions exist among the medical community  about  CAMs
therapy benefits and limitations?  






16.  What service component is most likely to be necessary in the 
acceptance of CAMs therapeutics in the medical community?





====================

Potential Assessment
 
17.  What time horizon  exists  for  CAMs  therapy  products  and
services as applied to the treatment of inflammatory diseases?  






18.   What  pressing  opportunities  exist  right  now  for   the
application of CAMs in the treatment of inflammatory diseases?  






19.  What will be the predominant need ten years from now? 





20.  How much might CAMs therapy cost  in  treating  inflammatory
diseases?








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