General interest question / alcohol metabolism

J R Small eang95 at
Mon Feb 21 05:47:51 EST 1994

In article <199402182347.PAA16503 at> SCHLOSSER at (Paul Schlosser) writes:
>Drinking alcohol causes induction of cytochrome P450 2E1 (in the liver),
>a principle enzyme in alcohol metabolism.  So as your average consumption
>goes up, so does your metabolism.
>Paul Schlosser
>Chemical Industry Institute of Toxicology
>schlosser at

Yes, but as you are aware, metabolism does not always increase in a
linear fashion when enzyme activity is increased. There may come a point
where alcohol levels will essentially 'saturate' the alcohol
metabolizing system.

Rankin Small
University of Edinburgh.

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