alcohol metabolism

Stephen Marshall marshall at
Tue Feb 22 17:49:39 EST 1994

In article <Pine.3.05.9402201113.A3789-b100000 at>,
guia at CC.UManitoba.CA (Antonio Guia) wrote:

> Considering that alcohol is not inhaled too, there is a considerable first
> pass effect through the liver, just as anything injested will enter the
> body through the portal system, taking it through the liver first before
> getting into the circulation.
> -tg

The main first pass affect on ethanol is in the esophagus/gut. Substantial
alcohol dehydrogenase and aldehyde dehydrogenase activity exists in the
linings of the esophagus and gut. This is part of the difference between
the capacities of men and women to consume alcohol.

The liver is where most of the detoxication of blood ethanol and
acetaldehyde occurs, although the blood also has aldehyde dehydrogenase
activity which can help with any acetaldehyde that escapes the liver.

Macintosh Consultant                              Marshall at
Victoria University of Wellington
New Zealand

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