World's Smallest Transcription Factor

[lsalati at wvnvms.wvnet.edu]

In article <genecutl-230294002242 at kos2mac23.berkeley.edu>, genecutl at mendel.berkeley.edu (gc) writes:
> 
> I'm trying to find out how many small transcription factors have been
> characterized, but that's a tough thing to do a lit search on.  I'm
> looking for any transcription factors that people know of smaller than
> say thirty kilodaltons.


GC,
 
The ICER family of transcription factors is one candidate.  They
are derived from a downstream promoter in the CREM gene.  At least
2 of these proteins are 18 and 19.5 kd.  Essential expt is
transfection of an expression plasmid for the ICER cDNA and another
plasmid with ICER binding sites linked to CAT.
 
Ref:
Inducibility and negative autoregulation of CREM: An alternative
promoter directs the expression of ICER, an early response repressor.
Cell 75:875-886, 1993.
 
Steve K.