Question about Mg & Mn as enzyme cofactor

[Cornelius Krasel]

library (blai at eniac.seas.upenn.edu) wrote:

: I learn that both Mg ion and Mn ion can play as Phosphotransferases cofactor.
: Can these two kinds of ions substitute for each other? Can Mn ion
: activate ATP?  Is there a paper or book saying about this question?

Mn can often replace Mg in phosphotransferase reactions, but as I
understand it, not always.

Sorry, no reference. (You can find this scattered throughout basic
biochemistry books.)

--Cornelius.

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