immune transplant for treating hiv or organ rejection

Shahram Mori smori at opus.nmsu.edu
Thu Jun 2 00:43:31 EST 1994


ADAM MUNDAY (admun1 at MFS03.cc.monash.edu.au) wrote:
: In article <2qnrni$mu5 at rc1.vub.ac.be> tsornas at dec5.ulb.ac.be (Thierry Sornasse) writes:
: >From: tsornas at dec5.ulb.ac.be (Thierry Sornasse)
: >Subject: Re: immune transplant for treating hiv or organ rejection
: >Date: 10 May 1994 11:38:26 GMT
: >In article <2qn1j7$67j at eagle.natinst.com>, klopfer at natinst.com (Mike Klopfer) writes:
: >|> 
: >|> I read somewhere about transplanting a functioning human immune system
: >|> into SCID mice. I was wondering if there are other examples of transplanting
: >|> immune systems between species. I was wondering if this could be a potential
: >|> treatment for hiv e.g. using the immune sytem of a species that isn't 
: >|> susceptible to the virus to replace the immune system of the hiv infected
: >|> person.
: >|> 
: >|> Along this line I've heard of a treatment (maybe it was called Total
: >|> Lymphoid Irradiation) using radiation to destroy a persons immune
: >|> system. Then the immune system can be restarted from saved stem cells
: >|> possibly eliminating rejection of transplanted organs. I was wondering
: >|> if something like this is being tried or used? If this is not successfull I 
: >|> would also be interested in finding out what is the best guess as to why not.
: >|> 
: >|> Thanks for your time.
: >|> 
: >|> mike
: >|> 

No Way. HIV infects many other tissues such as stem cells and epithelial
cells. The Stem cells especially act as resevoirs of the Virus. 
Cheers
Shahram Mori
Program in Molecular Biology 
Dept. of Chemistry and Biochemistry
NMSU Las Cruces NM
88003 

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