Pre-mRNA splicing-- kinetic control?
genecutl at mendel.berkeley.edu
Wed Mar 9 18:42:50 EST 1994
In article <2lj17b$b4d at lace.Colorado.EDU>, eesnyder at beagle (Eric E. Snyder)
> I have been trying to find a couple of references which support
> or refute the following hypothesis:
> Pre-mRNA is or can be spliced differently depending on how quickly
> it is synthesized.
> I have developed an computer program (NAR 21(3): 607-613) which predicts
> the intron-exon structure of human genes (and thus the splicing pattern)
> using a dynamic programming. The algorithm implicitly assumes splicing
> starts with the whole transcript. However, clearly the 3'-end of the
> transcript is hanging out in space for a while before the transcript is
> finished. The question is, does this make a difference? Has anyone
> seen any papers that address this possibility directly? Lots of people
> claim that it might be true but I have never seen an experiment testing
If it helps any, I've seen scanning electron microsope pictures of what
are supposed to be snRNP complexes on RNA as it is still being transcribed.
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