Inhibition of Interactions between Integrins and Neo-synthesized Fibronectin

Tue Apr 25 12:47:07 EST 1995

I would like to block interactions between integrins and different 
neo-synthesized fibronectin isoforms by coating specific mAbs on culture 
dishes just before plating my cells.  In such way I do hope to be able to 
inhibit interactions between integrins and growth factors neo-induced 
fibronectin isoforms.

Is it the correct approach to the problem?
If yes, which kind of plastic dish have I to use?

Technical and strategy comments are welcome.

Thank you very much  in advance for your suggestions.

                   Guido SERINI
                   Centre Médical Universitaire (CMU)
                   University of Geneva

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