CALL FOR DISCUSSION: RECOMBINATION/bionet.molbio.recombination

BIOSCI Administrator biosci-help at
Thu Aug 17 17:46:22 EST 1995

We have received a proposal below for a new newsgroup,


Discussion on the following proposal will now be open through 27 August
on BIOFORUM/bionet.general (*not* on BIONEWS/bionet.announce).  For
those who are not on the BIOFORUM/bionet.general newsgroup currently,
either read bionet.general on USENET or contact one of the following
biosci addresses to sign up by e-mail:

Subscription Address                 Location
--------------------                 --------
biosci at               Europe, Africa, and Central Asia
biosci at                   Americas and the Pacific Rim

One warning, however: BIOFORUM/bionet.general is a "chatty" newsgroup
and many other items will be discussed there besides this newsgroup
proposal.  USENET news access is definitely better than e-mail if you
want to monitor only this discussion.

Discussion Guidelines
Please do not post one-line messages saying things like "I am in favor
of such a newsgroup".  We will collect votes later.  The discussion
period is an opportunity for anyone to bring up reservations about the
proposed charter below and to propose modifications prior to the vote.
If the charter is perfect as is, then there is no need for anyone to
say anything!!!

The newsgroup discussion leader may submit a revised proposal in light
of the discussion, and the new charter would be included in the call
for votes which will go out on 28 August (Newsgroup Discussion leaders -
please note this deadline - if no revisions are received before the
deadline, the original charter will be voted on.).

Please be aware that only one vote is counted per e-mail address, so
it is necessary to have your own account in order to vote.  Multiple
votes from the same address are not accepted.  If you are interested
in the following newsgroup, but do not have an e-mail address of your
own, please obtain one from your computer center before the call for
votes is issued.

Proposal to establish RECOMBINATION/bionet.molbio.recombination

Proposed USENET name:           bionet.molbio.recombination  (unmoderated)

Proposed mailing list name:     RECOMBINATION

Proposed e-mail addresses:      recom at
                                recom at

Discussion leaders:

*Note: Area of expertise is written in brackets

Graham Dellaire,  e-mail: popa0206 at (b2xe at
Department of Medicine (Div. of Exp. Medicine)
McGill Univeristy,
Montreal, Quebec, Canada 
*(Genome Accessibility, Line-1 sequences, Gene Conversion and Ectopic Int.)

George Szatmari,  e-mail: szat at
Assistant Professor
Departement de Microbiologie et Immunologie
Universite de Montreal
CP 6128 Succursale Centre-Ville
Montreal, Quebec H3C 3J7
phone (514)343 5767  fax (514)343 5701
*(Site Specific Recombination Sytems)

Terry Chow e-mail: MDTY at
Associate Professor
Department of Oncology
Division of Radiation-Oncology
McGill University
Montreal General Hospital
1650 Ave. Cedar
Montreal, Quebec H3G 1A4
phone (514)934 8040 ext. 4179
fax (514)934 8220
*(Mammalian Genetics/gene therapy)

Dana Lasko e-mail: CZDL at
Assistant Professor of Medicine and Human Genetics
Project Director
Terry Fox Molecular Oncology Group
Lady Davis Institute for Medical Research
3755 Cote-Ste-Catherine Rd.
Montreal, PQ
Phone 340-8260 ext. 3454 (office and machine) or  ext. 5251 (lab)
Fax 340-7502
*(Replication and Recombination)


The purpose of the RECOMBINATION newsgroup is to provide a proper
forum for the discussion of issues pertaining and involving recombination 
of DNA or RNA, in its many forms (see _Topics of Discussion_).  Primarily 
it should enable those researchers who work in recombination or aligned 
fields to communicate ideas and information, as well as, provide a chance 
collaboration among national and international research groups.

Topics of Discussion include:
1. Gene conversion and ectopic integration 
2. Genome accessibility and nuclear/chromosome structure and recombination
                    -Matrix attachment sites (MARS)
                    -nucleosomes, histone 1 
                    -recombination hotspots
                    -fragile sites 
                    -origins of replication
3. Effect of DNA topology on recombination (Triple strand, Z-DNA, cruciform, 
bent etc)
4. Homologous recombination vs. nonhomologous or illegitimate 
                    -comparisons between bacterial, yeast and higher 
eukaryotic recombination
                     systems (ex. fungi, mammals) 
5. Models of recombination (One-end invasion, Double strand Break Repair, 
SSA etc)
6. Site-specific recombination systems (invertase, Cre and Flp recombinase 
7. Specific recombination systems in complex organisms
                    -VDJ recombination
                    -Antigenic variation and recombination (ex. 
trypanosomes, HIV, N.gonorrhea) 
                    -Yeast mating type locus 
8. Transcription and recombination 
9. DNA replication and recombination (ex. gene amplification (DHFR etc))
10. Evolution of the Genome
                    -retroposons (Line-1, Sine's), retroviruses and 
                    -formation of gene clusters and comparative mapping
                    -recombination between other repeat elements (alpha 
satellites, telomeres)
11. DNA repair systems and recombination (DSB and mismatch repair)
                    -including DNA repair deficient diseases (ex. Xoderma 
12. Applications of recombination
                    -Gene therapy
                    -Transgenics and gene transfer
13. Viral diversity through RNA recombination
14. Population genetics and recombination:i.e. as a source of allelic 
and as a measure of genetic exchange within and between populations.

In addition this newsgroup provides:

        A forum for the exchange of information about future congresses
        and meetings in areas of molecular biology relating to recombination

        A forum for the exchange of information about textbooks, internet
        resources, visual materials, and computer programs.

        A source of quick help for last-minute troubleshooting, sources of 
        and practical advice; in areas such as
                     -Vector design for transgene experiments
                     -Gene transfer techniques
                     -Animal models and cell lines
                     -Gene therapy protocols 

Subscribers are welcome.  Contributions within the functions outlined
above are encouraged.

The newsgroup is -UNMODERATED-.

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