Cloning--a novel idea
gwmartin at scunix4.harvard.edu
Fri Aug 25 13:48:45 EST 1995
matkisso at opal.tufts.edu wrote:
: > Human erythrocytes do not contain DNA, correct. Other cells found
: > in blood do.
: Point of curiosity: Unless some rare circulating stem cell happened to be
: present, wouldn't the B and T cell DNA in the blood belong to committed cells
: whose antigen recognition repertoire has been determined? Presuming you could
: clone the whole individual human, is it reasonable to think the clone would be,
: for all practical purposes, immunodeficient?
This is a good point. Mature B and T cells have large deletions in
the Ig and TCR loci. But what I wonder is what the proportion of B and T
cells is to the other circulating leukocytes, which would not have
rearranged (as far as we know) genomes. Anybody got info on this?
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