lysosomal enzymes

fungomorph at pi.net fungomorph at pi.net
Fri Dec 1 18:59:28 EST 1995


In article <48tqnk$ldo at mserv1.dl.ac.uk>, <oktem at fen.bilkent.edu.tr> writes:
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> From: Emre Oktem <oktem at fen.bilkent.edu.tr>
> Newsgroups: bionet.general
> Subject: lysosomal enzymes
> Date: 22 Nov 1995 00:26:28 -0000
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> Sender: lpddist at mserv1.dl.ac.uk
> Distribution: bionet
> Message-ID: <48tqnk$ldo at mserv1.dl.ac.uk>
> Original-To: bioforum at dl.ac.uk
> 
> Is there anyone who knows why hydrolytic enzymes inside the lysosome do 
> not degrade the lysosomal membrane?
> 
> The hydrolytic enzymes perform their activity in a narrow range of pH 
values. They must also be in a monomeric state for lytic function. The 
cations play a role as a catalysator. Intact lysosomal cellular membrane 
serves keeping hydrolytic enzymes of lysosome in an inactive state. When the 
integrity of the membrane is disturbed, the micro-environmental pH changes 
in favor of enzymatic activity and monomeric state which function as a 
trigger mechanism to the activation of lysosomal enzymes. An inactivated 
lysosome has thus always an intact membrane. 




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