NEW bandage material??

mail02161 at mail02161 at
Wed Dec 6 15:04:23 EST 1995


We are trying to determine if a bioactive wound dressing material described 
below is novel/interesting or whether it is completely redundant with 
technologies that already exist.

The key to the technology is the use of covalent bonds to bond a wound-healing 
material (in this case, (trypsin) directly to the fiber.
The main objectives of covalent bonding of the bioactive material to
the fiber substrate were five-fold:

1. To increase the time during which the bioactive material interacts
with the wound "cleaning" and healing it. The results are:
if trypsin is applied to the wound in form of a powder it works for
30 min.-1 hour and then is "washed out" by the liquid produced in the
wound, if in form of an ointment - up to 2 hours, in form of the new
bandage - 72 hours.

2. To decrease the amount of the bioactive material used while
retaining the healing effect unchanged (which in some cases such as
anti-cancer drugs is important not only because of the cost but
also due to unfavorable side effects). The result is: in case of the
trypsin 3 x 3 inch bandage only 4 mg of the active are used;
in case of anti-cancer drug its amount is reduced by 30 times.

3. To make the healing material cheap. The result is: as the main 
cost is the cost of the bioactive material reducing its amount effectively cuts 
the cost..

4. To make the use of the material simple. The result is: to be used, the 
bandage is to be taken out of a sterilized package, soaked in warm
water and applied to the wound.

5. To solve the problem of sterilization because trypsin becomes inactive
if heated over 40 degrees C or if sterilized by radiation. The result 
is: it turned out the when trypsin is covalent bonded to cellulose fiber
the latter becomes its "protector" against negative effects of gamma
radiation and this allows to have bandages effectively sterilized by
standard gamma radiation sterilization devices during the production

If anybody has any ideas about whether the technology is interesting, I would 
be grateful for any informal comments.

Thanks in advance.

Dell Wilkinson
mail02161 at
(703) 476-2222
(703) 476-2221

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