MES Buffer

Heino Prinz heino.prinz at mpi-dortmund.mpg.de
Tue Jan 24 04:49:47 EST 1995


In article <3fm9k6$k86 at portal.vpharm.com>, Black at vpharm.com (Blackus) says:
>
>Has anyone ever noticed the pH drifting while  a MES buffer is stored. 
>I've gained a pH unit a day for 2 days and am wondering if this is
>something to watch out for with MES.

 At which pH are you working? MES is best at its pK=6.15, so you
may be in trouble if you try to buffer at pH8.

Also, MES is not very soluble, a saturated solution at zero degrees
would be 0.65 M. If you have tried to make a more concentrated solution,
it would not be equilibrated.

Good luck!		Heino



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