Vitamin K -- info please
pieter.proot at med.kuleuven.ac.be
Tue Mar 7 08:47:34 EST 1995
In article <3j53kb$kfg at rebecca.albany.edu>, tivol at tethys.ph.albany.edu wrote:
> In article <NEWTNews.4369.793676556.CROBBINSON@
> c110.globalvision.net.globalvision.net>, crobinson at globalvision.net writes:
> >I am attempting to find out the function of vitamin K (on a molecular level)
> >in the body. [snip] I am also wondering as to how many type of Vitamin K
History: Vit K was discovered in 1929 by Dam. He found that chickens on
a certain diet developped spontaneous bleedings, due to a low prothrombine
level in the blood. Six years later he discovered that is was because of
a fatty product he then called Koagulations Vitamin (German): Vit K.
Two natural vit K products were discovered: Vit K1 (VK1) and Vit K2
(VK2). First synthesis of VK1 was in 1939 by Fieser. However, many
different chinonderivatives were discovered that had VK activity.
Structuree & properties: VK is soluble in fatty solutions. It is
available in many plant derived oils. The product is light sensitive, but
it is rather resistant against heat.
VK1 and VK2 are naphtochinonderivatives (sorry: no structure can be send
this way, but they can easily be found in the Merck Index, centennial
edition). Several synthetic derivatives are available, see table below:
VK1 Fyllochinon 2-methyl-3-fytyl-1,4-naphtochinon from patatoes etc
VK2 Farnochinon 2-methyl-3-farnesyl-digeranyl-1,4-naphtochinon (bacteria)
VK3 Menadion 2-methyl-1,4-naphtochinon synthetic
VK4 Menadiol 2-methyl-1,4-naphtohydrochinon synthetic
VK5 4-amino-2-methylnaphtol "
VK6 2-methyl-1,4-diaminonaphtol "
VK7 4-amino-3-methylnaphtol "
Since the natural products are not soluble in water, a bisulphite
derivative is used.
Biochemical role of the vitamine can easily be found in any textbook of
biochemistry and/or physiology. Note that the vitamine has an important
role in bloodcoagulation.
Hope this helps.
Pieter Proot, Pharm e-mail: Pieter.Proot at med.kuleuven.ac.be
Katholieke Universiteit Leuven
Laboratory of PHYSIOLOGY,
O&N Gasthuisberg, Herestraat 49
B-3000 Leuven, BELGIUM
Tel: + 32 16 34 57 27 Fax: + 32 16 34 59 91
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