Funky bacterial insulin

[CABC/W95]

 Greetings all!
I do wonder if any of those brains out there can help me. Anybody ever 
heard of Humulin?  It is microbially produced human insulin (I think the 
organism of choice is Escherichia coli). I'm a biochem / micro major 
doing a research paper on industrial production of Humulin, only problem 
is that the production, I believe, is patented, so information (on an 
industrial scale) is limited. Any help would be greatly appreciated! Thanks!