Recipe for Immortality - Revised

Ann Tekatch a7503934 at mcmail.cis.mcmaster.ca
Sat Oct 7 10:53:04 EST 1995


FROM: Bill Tekatch <a7503934 at mcmail.cis.mcmaster.ca>

Due to several requests for copies of the recipe, I have decided to
slightly revise it and re-post.  I have included some suggestions by
newsgroup readers.  Please, if you can think of other methods or
alternative therapies post them.  Also if you see possible work
arounds for any of the several difficult steps in the recipe, share
them with us.  I do not know of anyone currently using the recipe,
and it has not been published elsewhere.

Notes & Cautions

* While the recipe may someday be accepted as the
basis of a life extending therapy, it will not give you
true immortality.

* We will still be subject to death by disease and accident.

* Natural memory loss may still continue.

* The build up and cross linking of insoluble collagen will cause ever
increasing body stiffness.

* The fragmentation of elastin will cause the loss of blood vessel
wall elasticity.

* If the death rate not related to ageing is only 0.5%/yr, there will be
fewer than 1% that will live to 1000 years old.  In fact only 50%
would live to over 138 years.  A more optimistic estimate based on a
0.1% per year death rate gives 50% survival to 700 years and 1% to
4600 years.

* We still need a cure for cancers such as prostrate cancer which
would eventually kill every male that survives long enough.

* This process if carried out on the entire population would likely
consume 5-10% of GNP.  Is the cost justified?

* This list of problems is not complete.  I am sure there are many
more problems that could be added, but that does not mean the
recipe does not have merit.


For Your Information:

L=5.5^0.54 S^-0.34 M^-0.42

Where		(L) is mammalian life-span in months
		(E) is brain mass in grams
		(S) is body mass in grams
and		(M) is metabolic rate in calories per gram per hour

*****************************************
This is the recipe for immortality.

The latest results in the fields of genetic engineering, reproductive
technology, and cancer research have provided a foundation for the
recipe for immortality.  In normal cells, the telomeres or end
segments of chromosomes, are slightly shortened each time the cell
divides.  With the accumulated shortening of the telomeres, the
chromosome becomes too short to divide.  This process is repeated
for all of the cells in the organism.  Therefore, eventually the
organism will not be able to reproduce enough new cells to maintain
life.

Nature has been using a method to circumvent this problem with
good success for some time.  While sexual reproduction can allow a
species to maintain itself, the individual organism is less fortunate.
To achieve immortality in a multicellular organism it is necessary to
regenerate full length chromosomes essentially identical to the state
of the existing chromosomes at fertilization.  It is not necessary to do
this in the existing cells.  Artificially prepared cells can be introduced
into the organism.  This is the basis for Repetitive Internal Self
Cloning (RISC).

Female Immortality by RISC

An egg cell from the organism is injected with the DNA taken from
another egg cell from the same organism.  Alternatively the egg cell
might be stimulated to develop by parthenogenesis.  This self
fertilized cell is allowed to divide to just short of the point of
differentiation.  The cells are then introduced into the organism by
the blood stream.  They will circulate throughout the body and tunnel
to all regions.  In a short time these new cells will differentiate to
become identical to the surrounding tissue, with one very important
difference.  These new cells are capable of many more divisions
than their neighbours.  The progeny of these new cells will gradually
replace the cells of the surrounding tissue as they eventually die off.
This process must be repeated approximately every seven years to
ensure a continuous supply of fresh cells.  The living mass must be
maintained above the critical level at all times lest the entire
organism dies.  The most critical time will occur when the organisms'
birth cells are dying en masse.  The mass of new cells must be
sufficient so that the organism does not go into the cell death chain
reaction.

Male Immortality by Risc

All factors are the same as for the female but the method is
different.  An egg cell is required.  The donor egg mitochondrial DNA
must be compatible with the organism.  Therefore the egg must be
from the organisms' mother or sister or a verified match.  The
original DNA is removed from the egg leaving all of the organelles
intact.  Then the DNA of two sperm cells from the organism is
introduced into the egg.  This must be repeated more than is
required for the female as only the cells containing the XY pair can
be used.  The artificially produced cell is then cultured and
introduced in the same manner as for the female technique.

* no references *
* no bibliography *

Humbly yours,
Bill Tekatch






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