essential amino acids (methionine) biosynthesis ?
nmarsden at acs.ryerson.ca
Tue Feb 6 11:24:54 EST 1996
George M. Carter (gmc0 at ix.netcom.com) wrote:
: Peter.Kulmburg at AUG.UKL.UNI-FREIBURG.DE
: (kulmburg at aug.ukl.uni-freiburg.de) wrote:
: Obviously, there is more to amino acid production than just enzymes
: (since various amino acids can be converted to others). Such a
: differential analysis of pathways of amino acid production would be
: interesting to see but beyond the scope of a quick email. Does anyone
: here have good references for this kind of thing? And what is the
: rationale for wanting to know "what's missing" (so to speak) from
: humans that cannot synthesize essential aa's?
>>>>>>Essentially, though, every anabolic and catabolic pathway in the
body is regulated by enzymes and coenzymes! The only way a molecule can
be transformed into another (eg: one amino acid to another) is through
the action of a specific enzyme and its cofactor. Therefore, what is
either missing or defective is probably an enzyme for that particular
reaction. Genetic predisposition can render faulty coding for the primary
polypep. sequence causing either reduced, enhanced, or no activity.
I've forgotten what the original question was but I'll gladly
check my biochem. books for any info. you need.
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