Job Posting (Lady Davis Institute (Montreal))

[Graham Dellaire]

Job Listing #2: 

Characterization of The RNA Binding Ability of SAM68

Dr.Stéphan Richard, Ph.D 

Lady Davis Institute for Medical Research 
Montreal, Quebec, Canada 

Project description: 

The focus of our laboratory is on signal transduction mediated by 
tyrosine kinases. We have previously discovered Sam68 which is a fyn, 
src family tyrosine kinase which binds SH3 domains. Further we have
demonstrated that many other proteins with SH3 and SH2 domains bind 
Sam68 including ras-GTPase activating protein (GAP), phospholipase C-1 
and Grb2 (Mol. Cell. Biol. 1995, 15:186). Sam68 defines a family of 
proteins that bind signal transduction molecules and RNA. Interestingly, 
phosphorylation of this protein abolishes its ability to bind RNA(J. 
Biol. Chem. 1995, 270:2010). 

Specifically the aims of the project are: 

   1.to delineate the RNA binding domains of Sam68 and to understand the 
mechanism by which
     phosphorylation abolishes RNA binding. 
   2.to identify physiologcal targets for the RNA binding daomain of 
Sam68. 

The student will gain knowledge in signal transduction, as well as 
techniques in molecular biology, cell
culture, phosphorylation and immunology. 

Positions:

     Ph.D. Postion 

          -to qualify, applicants must have a B.Sc. in molecular 	
  biology, biochemistry or immunology
          in addition to obtaining a GPA of greater than 3.4.


To Apply:

Please send your curriculum vitae and a copy of your transcript to: 

Dr. Stéphan Richard 

Lady Davis Institute
3755 Cote St. Catherine Road
Montreal, Quebec
Canada H3T 1E2

mcrd at musica.mcgill.ca 

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http://www.medcor.mcgill.ca/EXPMED/DOCS/jobs.html