eHand/dHand and Cardiogenesis....bHLH rear their head again!!!

[Graham Dellaire]

"Subclass of bHLH Proteins Required for Cardiac Morphogenesis"

Sriastava, Cjserjesi and Olson (Science,Vol 270  Dec 22, 1995)


I was wondering what the general response to this paper was.

I think many people may have been surprised to see a bHLH protein in cardiogenesis after such a
long unfruitful search by others in the past. 

I know many people are betting on the GATA family of transcription factors as playing a major role in 
cardiac muscle development.


ANy one have any opinions on this?   Where would you go next.... DD-PCR to find the genes that the putative transcription 
factors eHAND and dHAND activate or regulate?  


Please post any comments to 

dellaire at odyssee.net
or 
popa0206 at po-box.mcgill.ca

as my local news feed for lack of a better word... "SUCKS!"