Molecular Traffic in Fast Acting Enzymes

Simone Botti csbotti at
Wed Feb 14 13:18:36 EST 1996


I was wondering if any body could help me find general references or reviews 
dealing with substrate steering and product clearance to and from the active site 
of enzymes that approach the so-called limit of diffusion.
 ( e.g. Superoxide dismutase Carbonic anhydrase and Acetylcholinesterase )
The focus would be more on the actual force fields and mechanics involved in 
steering the product towards the active site and then clearing the site for the next  
catalytic event.

An interesting spin-off would be if the reviews dealt with the thermodynamic 
treatment of "crowded biological  systems" 

Thank you very much in advance.

Simone Botti 
No Fixed Physical Location
Simone is delocalized over these physical locations:
                 		Weizmann Institute of Science
Dept.of Structural Biology              Dept.of Neurobiology
Kimmelman Building, room 663    Meyer Building, room 411
                    												76100 Rehovot, Israel
vox.  +972 8 9343759                    vox. +972 8 9342128
                   fax  : +972 8 9344159       
            E-Mail :csbotti at

More information about the Bioforum mailing list