Molecular Traffic in Fast Acting Enzymes

[Simone Botti]

Greetings,

I was wondering if any body could help me find general references or reviews 
dealing with substrate steering and product clearance to and from the active site 
of enzymes that approach the so-called limit of diffusion.
 ( e.g. Superoxide dismutase Carbonic anhydrase and Acetylcholinesterase )
The focus would be more on the actual force fields and mechanics involved in 
steering the product towards the active site and then clearing the site for the next  
catalytic event.

An interesting spin-off would be if the reviews dealt with the thermodynamic 
treatment of "crowded biological  systems" 

Thank you very much in advance.


-- 
Simone Botti 
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