Kari Airenne airenne at
Thu Feb 29 04:43:35 EST 1996

The 6th International Summer School, Jyv{skyl{, Finland,
August 5 - 30, 1996

The 6th International Summer School offers advanced undergraduate and
early graduate level students intensive lecture courses from a week to
two weeks of duration. The instruction will  be in English. This year 18
courses are given in
	mathematics and applied mathematics
	computer science and information systems
The extent of lecture courses varies from 15 to 60 hours per course and
each course has 1 to 4 teachers, with the exception of biology courses,
that have a number of teachers. To pass a course and to get full credits
a student has to pass an exam successfully or to solve practical problems
(min. 50%) during the course. For those students who only want to listen
to the courses a certificate of attendance is given (min. 50 % attendance
activity). We have kept the level of teaching as high as possible by
inviting high level lecturers from Europe and USA. The Summer School is
educational rather than scientific.

In the 5th International Summer School there were 390 participants from
26 different countries. Fourty percent of the students came outside
Finland, mostly from Europe, but also from America and Asia.


To apply for the International Summer School, please, fill in the
application form on our WWW-pages or in the brochure.  Send it and a
description of your studies (or CV) to the organizers by March 31, 1996.
The Organizing Committee will select the participants based on the

Accommodation and fees

The courses are free of charge. Participants can choose their
accommodation between modern student apartments, summer hotel and hotel.
The approximate cost for housing is as follows: student apartment 1000
FIM/ month and  600 FIM/ two weeks, summer hotel 150 FIM/ night and hotel
300 FIM/ night. Each participant is responsible for his/her own housing,
living and travel expenses. The rent of the student apartment is
requested to be paid in advance in May. Full refund can be made if
cancellation is received by July 1, 1996. We can help with the room
reservations in the summer hotel and hotels.

The City of Jyv{skyl{

The City of Jyv{skyl{ is located in Central Finland, which is known for
its beautiful lakes, ridges, fields and forests. The economy of Central
Finland is based on the modern pulp and paper industry. The City of
Jyv{skyl{ with a population of 74 000, is the site of the The 1000 Lakes
Rally, which has been held in August since 1950. Jyv{skyl{ and its
surroundings offer numerous recreational activities including swimming,
golf, track and field, hiking, fishing, canoeing, and lake cruises.

Further information

The programme will be subject to minor alterations. For updated programme
and the latest information see our WWW- pages.  More detailed information
on the International Summer School will be sent to accepted students in

Organizing Committee:

Prof. Jouko Korppi-Tommola, chairman
Study Administrator Leena Kirkkom{ki
(Faculty of Mathematics and Natural Science)
Asso.Prof. Pekka Koskela
Asso.Prof. Anita Mikkonen
Asso.Prof. Matti Leino
Asso.Prof. Mauri Lepp{nen
(Computer Science and Information Systems)
Asso.Prof. Timo Tiihonen
(Applied Mathematics)
MSc Kirsti Laapio, secretary
(Faculty of Mathematics and Natural Science)

Summer School address:

The 6th International Summer School
Faculty of Mathematics and Natural Science
University of Jyv{skyl{
P.O. Box 35
FIN-40351 Jyv{skyl{

Phone: +358 41 602 206
Fax: +358 41 602 201
E-mail and WWW addresses:=20
iss at


The programme may be subject to minor alterations. For updated programme
see our WWW-pages.


PH 1 Classical and Quantum Dynamics of Mesoscopic Josephson Junctions, 
20h, August 5 - 9
The lectures will present basic ideas and some of the recent developments
in understanding of classical and quantum dynamics of superconducting
quantum point contacts and other high-transparency Josephson junctions.
The classical dynamics of these systems is markedly different from
dynamics of "regular" small-transparency tunnel junctions due to an
important role played by the processes of multiple Andreev reflection
(MAR). One of the unusual consequences of MAR is the giant supercurrent
noise in quantum point contacts. The quantum dynamics of the Josephson
phase difference leads to a variety of macroscopic quantum effects in
small Josephson junctions. I will discuss quantitative theory of these
effects in high-transparency junctions.
Prof. D. V. Averin, State University of New York at Stony Brook, USA.

PH 2 Modern Methods in Statistical Physics,
30 h, August  5 - 16
This course deals with concepts and techniques used in modern statistical
and condensed matter physics, with particular emphasis on the theory of
phase transitions and critical phenomena. The course begins with a short
review on thermodynamics and statistical mechanics, including special
topics such as the termodynamics of interfaces and percolation theory.
These are followed by a detailed account on scaling in static,
equilibrium and nonequilibrium phenomena, Landau theory, Langevin
equations, and the Renormalization Group. The course is intended for
beginning and intermediate graduate students with a good basic knowledge
in statistical and quantum physics.
Course book: N. Goldenfeld, Lectures on Phase Transitions and the
Renormalization Group, Addison-Wesley (1992)
Dr. T. Ala-Nissil=E4, Research Institute for Theorethical Physics, Finland.

PH 3 The Standard Model to One Loop at Zero and Finite Temperature, 30 h,
August 5 - 16
The main topics will be: One-loop renormalization of scalar
electrodynamics and of the Standard Model. The relation of running
parameters to physical parameters. Standard Model at finite temperature:
equilibrium thermodynamics (pressure, properties of phase transitions),
the infrared problem, and the effective field theory approach. Gauge
independence of physical quantities.
Dr. M. Laine, University of Heidelberg, Germany.

PH 4 From the Nuclear Shell Model towards Collective Motion, 15 h, August 
19 - 23 
We shall present an overview of how recent developments in nuclear
structure studies, mainly concentrating on low-lying collective
excitations can be understood in the light of the nuclear shell model. We
shall start from the shell model and use this as a basis to construct
coherent modes of motion like low-lying isoscalar and higher-lying
isovector excitations. The outline of large-scale shell-model studies
will be discussed as well as the limitations when making applications to
light neutron-rich nuclei. Shell-model techniques and algebraic
approaches will be discussed in the light of better understanding various
symmetry concepts used in describing nuclear collective quadrupole
motion. Besides attemps to relate fermion to boson model descriptions, a
number of basic principles related to symmetry concepts underlying
interacting boson models will be worked out.
Prof. K. Heyde, Institute for Theorethical Physics, Belgium.

PH 5 Quantum Dynamics  and Collective Behaviour in Modern Atomic,
Molecular and Optical Physics, 30 h, August 19 - 30
This course gives a basic introduction to the techniques used in
describing the interaction of laser light with atoms and molecules. The
main emphasis is on time-dependent systems and their properties. The
presentation of the methods and tools is closely combined with the latest
advances in atomic, molecular and optical physics. Among them are
ultracold atomic collisions, Bose-Einstein condensation of gaseous alkali
atoms, manipulation of molecular processes with femtosecond pulses, and
proposals for first-generation quantum computers. Related to the quantum
computers, an introduction to quantum computation (quantum gates and
networks) and decoherence is provided.
Dr. K.-A. Suominen, University of Helsinki, Finland.

PH 6  Future Directions of Nuclear Spectroscopy, 15 h, August 26 - 30
Referring to the pioneer Conference in Lysekil, 1966, this series of
lectures will be dealing with the question "Why and how should we
investigate nuclides far off the stability line". The lectures will focus
on selected topics, which are essential nowadays for development of
nuclear-structure concepts, determination of the weak-interaction
coupling constants, and a better understanding of nucleosynthesis
processes occurring in stellar environments. In particular, the following
questions will be considered: i) Gamow-Teller beta decay of doubly-magic
nuclides and their neighbours, ii) tracing the proton drip-line below Z =
50, iii) search for ground-state emission of two protons and iv)
high-energy isomers far from the line of stability on the neutron-rich
Prof. J.  ylicz, Warsaw University, Poland.


BIO 1 Protein Purification and Characterization, 60h, August 5 - 16
The course gives an introduction to basic techniques of protein
purification and characterization. The purpose of lectures, discussions
and practical demonstrations is to guide through the vast range of
methods in this field, while pointing out the advantages and
disadvantages of each, so that the choice can be made to suit the problem
at hand.
Prof. E. Bayer, Israel; Prof. A. Helenius, USA; Prof. K. Hiltunen,
Finland; Dr. M. Johnson, Finland; Prof. B. Jones, USA; Dr. N. Kalkkinen,
Finland; Prof. M. Kulomaa, Finland; Prof. P. M{enp{{, Finland; Prof. O.
Renkonen, Finland; Dr. J. Rouvinen, Finland; Dr. E. Sorensen, Denmark; Dr. K.
Takkinen, Finland; Prof. O. Teleman, Finland; Dr. T. Teeri,
Finland; Dr. G. Walsh, Ireland; Prof.  M. Wilcheck, Israel; Ms. M.
Vihinen-Ranta and Mr. K. Airenne (Organizers).

BIO 2 Genetic Information from Genes to Functional Proteins, 60 h, August
19 - 30
The course is focusing on gene regulation in different organisms,
posttranslational modification of proteins, and protein targeting
signals. Teaching includes lectures (40 h) and practicals (20 h). The
students prepare a short presentation about a given subjects. They also
have a chance to present the results of their own research projects.
J. Denecke, UK; A. Hille-Rehfeld, Germany; Dr. I. Braakman, the
Netherlands; Dr. S. Ker{nen, Finland; Prof. M. Kulomaa, Finland; Dr. M.
Penttil{, Finland; Dr. I. Saab, USA; Dr. R. Weinzierl, UK; Dr. \. Wrange,
Sweden; Dr. E.-L. Punnonen and Mr. I. Porali (Organizers).


CH 1 Laser Spectroscopy, 40 h, August 5 - 16
The first part of the course is devoted to wavelength resolved laser
methods such as high-resolution laser spectroscopy (small molecules),
classical Raman (liquid, powders), Resonance Raman (biomolecules)
spectroscopic methods and hole burning spectroscopy will be described.
The second part is devoted to time resolved laser methods, how to
generate pico and femtosecond light pulses and how to measure ultrafast
phenomena. Examples will be given on dynamic molecular events such as
molecular rotation, study of flexible molecules, solvation dynamics,
dissociation energy and electron transfer in molecular and photosynthetic
Prof. A. Freiberg, Tarto; Doc. E. Kauppi, Helsinki; Prof. J.
Korppi-Tommola, Jyv{skyl{ and Dr. M. Lutz, Paris.

CH 2 Macromolecules, 40 h, August 19 - 30
Structural methods in the study of proteins and polymers are described.
The course will focus in the methods to solve protein structure both in
solution and in crystalline state. Pulsed NMR technique in the study of
proteins in solution is described in detail. Also methods to prepare
protein crystals, collect their x-ray diffraction patterns and solving
their structure will be discussed. Basic polymer structures will be
described and their characterization via computational methods in the
study of macromolecules will be outlined. The course includes practical
modelling exercises.
Prof. T. Drakenberg, Helsinki; Prof. F. Muller-Plathe, Zurich and Dr. I.
Sinning, EMBL, Heidelberg.


The courses MA 1 - MA 4 form a summer school on free boundary problems,
that is supported by the ESF-Network 'Mathematical treatment of free
boundary problems'. We can provide some financial support for a limited
number of European participants. For details see our WWW-pages or contact
Dr. T. Tiihonen (tiihonen at

MA 1 Potential Theory for Elliptic and Parabolic Operators with Nonsmooth
Coefficients and Applications to Free Boundary Problems,
20 h, August 5 - 16
Part I. Potential Theory: 1. Harnack's inequality and interior Holder
continuity of local solutions. 2. Carleson's Boundary Harnack theorem. 3.
Estimates for harmonic measure and caloric measure. 4. Comparison
theorems. Part II. Applications: 1. Fatou theory. 2. Regularity of free
boundaries 3. Regularity by means of monotonicity.
Prof. E. B. Fabes, University of Minnesota, USA and Prof. C.  Kenig,
University of Chicago, USA.

MA 2 Phase Transitions, 20 h, August 5 - 16
Phase transitions can be induced by thermal and mechnical actions. In
some circumstaces an expected phase transition does not occur: this is
called supercooling phenomenon. Macroscopic predictive theories
describing these phenomena and some others will be presented. They use
the basic concepts of continuum thermodynamics, of convex analysis and of
partial differential equations. Basic examples will be treated, ice-water
phase change, supercooling, soil freezing, shape memory alloys,
irreversible phase changes etc.
Prof. M. Fr=E9mond, CNRS, Champs sur Marne,  France.

MA 3 Numerical Aspects of Parabolic Free Boundary Problems, 20 h, August
5 - 16
In this course we deal with the numerical approximation of various
parabolic free boundary problems: motion of interfaces under curvature,
phase change problems, phase transition problems. We introduce finite
element methods and discuss their convergence properties as well as their
efficient implementation. Numerical aspects and implementation details of
adaptive finite element methods in two and three dimensions will be
presented, as well as grid adaptation techniques based on error
indicators and estimators.
Prof. C. Verdi, University of Milan, Italy and Dr. A. Schmidt, University
of Freiburg, Germany.

MA 4  Variational Methods in Material Science: Phase Transitions,
Oscillations and Consentrations, 15 h, August 19 - 23
The study of material instabilities, such as phase transitions, formation
of defects, and the onset of microstructure in ordered materials, will be
undertaken from the point of view of the Calculus of Variations. New
mathematical techniques are introduced in the analysis of equilibria for
nonconvex problems, within a framework where variational models may
involve interfacial and bulk energy contributions. Topics include:
characterization of (sequentially) weakly lower semicontinuous
functionals; relaxation methods; interaction between concentrations and
oscillations -generalized measure-valued solutions, Young measures and
varifolds. Prof. I. Fonseca, Carnegie Mellon University, USA.

MA 5 Difference and Differential Equations in Stochastic Models in OR, 20h,
August 19 - 23
In this course we extensively study problems arising in the field of
production, communication and inventory systems. We focus on the
translation from problem to model. The models involve fluid flow models
for production and assembly lines and discrete Markovian models for
production systems and inventory control. The fluid flow models give rise
to differential equations. Techniques to find the exact and/or
approximate solutions are presented. Also numerical aspects are
discussed. This course is offered by ECMI.
Ass.Prof. J. van der Wal, Eindhoven University of Technology, the
Netherlands, Ass.Prof. I. Adan, Eindhoven University of Technology, the


CSI 1 Object-Oriented Database Systems: The Notion and the Issues, 20 h,
August 5 - 9
Object-oriented database systems have gained wide attention both in
database research and in industry due to their potential for managing
complex objects including structural information and behavioral
information. They are especially suited for so-called non-standard
applications including computer intergrated manufacturing and software
development environments. Object-oriented database systems are based both
on concepts from object-oriented languages and from traditional database
systems. The aim of the course is to provide a thorough introduction into
the concepts and implementation issues behind object-oriented database
systems and to discuss the state of art in terms of prototype systems
andJohannes Kepler University Linz, Austria.

CSI 2 Graph Theoretic models in Computer Science, 30 h, August 12 - 21
Part 1: Recent results on hypercube theory
Motivated by the increasing use of hypercubes in the architecture of
massively parallel computers, we are investigating their graph theoretic
structure. First, several equivalent characterizations and presentations
of hypercube, Q =3D Qn, are given. It is well known that Boolean functions
can be regarded as subsets of the node set of a hypercube. In fact,
Boolean algebras are representable as hypercubes. We shall discuss
cubical graphs and their cubical dimensions, spanning subgraphs of Q,
embedding into Q of arbitary graphs by subdivision of edges, Gray codes
as hamiltonian cycles, packing and mispacking, fault tolerance, and the
hamiltonicity of the middle bigraph  of odd Q.
Part 2: Fault tolerance in graphs and computer architectures
The use of graph theoretic models for studying fault tolerance in
computers was initiated by John Hayes in a pioneering 1976 paper. In this
approach, the failure of a processor is represented by the removal of a
node from the graph F of the computer architecture. One spare node is
added, together with additional edges, to construct a graph G with as few
edges as possibles, such that the deletion of any one node from G leaves
a graph which contains F. Then G is called optimally 1-node fault
tolerant of F. We also studied the edge fault tolerance and fault
tolerance of a general tree architecture. The connection with
connectivity in graphs will be emphasized.
Prof. F. Harary, New Mexico State University, USA.

CSI 3 Metamodelling and method engineering,
30 h, August 5 -16
Information systems analysis, design and implementation are being
transformed from an art into engineering discipline. One condition for
such a change is to improve our understanding and formalization of the
knowledge that is used, captured, transferred, and transformed during
systems development. This condition can be met by developing notations,
approaches and theories about systems development tasks and formal
representations of their outcomes and structure. This growing and
intensively researched area is called metamodelling, and the principles
and systematics of conducting metamodelling is method engineering. The
course will be conducted mainly as a series of sessions consisting of
lectures and workshops. Hands-on experience in metamodelling and method
engineering is provided in MetaCASE environment.
Prof. K. Lyytinen, Mr. S. Kelly, Mr. M. Rossi and Mr. J-P. Tolvanen,
University of Jyv{skyl{, Finland.

5-16 August 1996, Jyv{skyl{, Finland
(Preliminary program!)

Daily Program:

 9.00-11.00  Lecture
11.00-12.00  Lunch
12.00-13.30  Lecture
13.30-14.00  Coffee break
14.00-15.00  Lecture
15.30-       Demonstratiom

1. Week (5.8.1996-9.8.1996)

Mon 5.8 and Tue 6.8
Introduction, "Why purify proteins", and protein
purification from sample to crude extract.

Speaker:Dr. G. Walsh, University of Limerick, Ireland.

Wed 7.8
Gel filtration, electrophoresis, isolelectric
focusing,liquid phase partitioning, chromatofocusing.

Speakers:Prof. K. Hiltunen University of Oulu, Finland and
Dr. N. Kalkkinen, Institute of Biotechnology, Finland.

Thu 8.8 and Fri 9.8
Affinity adsorption chromatography, dye ligand
chromatography, ion-exchange chromatography, immunoadsorbents, hydrophobic
interaction chromatography and HPCL. Introduction to characterisation of
post-translational protein modifications.

Speakers:Prof. M. Wilchek and Prof. E. Bayer, The Weizmann Institute
of Science, Israel and Prof. A. Helenius, University of Yale, USA.

2. Week (12.8.1996-16.8.1996)

Mon 12.8
Characterisation of protein glycosylation and phosphorylation

Speakers:Prof. O. Renkonen, Institute of Biotechnology, Finland and
Prof. P. M{enp{{, University of Kuopio, Finland.

Tue 13.8
Analysis of protein structure
(sequencing and mass spectroscopy) and modifications.

Speakers: Dr. E. Sorensen, University of Aarhus, Denmark

Wed 14.8
Principles of analysis of protein structures by X-ray
christallography. Measuring biomolecular interactions in real time using an
optical based biosensor technology, theory and applications.

Speakers:       Dr. J. Rouvinen, University of Joensuu, Finland and Dr. Ingemar
Orsen and Dr. Helena Nilshans, Pharmacia Biosensor AB, Sweden.

Thu 15.8
Computer modelling of proteins.

Speakers:Prof. O. Teleman, VTT Biotechnology and Food Research,Finland
and Dr. M. Johnson, Turku Centre for Biotechnology, Finland.

Fri 16.8
Practical examples of protein engineering.

Speakers:Prof. M. Kulomaa, University of Jyv{skyl{, Finland;
Dr. K. Takkinen, VTT Biotechnology and Food Research, Finland and
Dr. T.Teeri,VTT Biotechnology and Food Research, Finland.

BIO 2 Genetic Information From Genes to Functional Proteins 

The scheduled program for BIO 2: 

                                Gene regulation in: 
mo      19.8.                   - Fungi                                  
                                Dr. Merja Penttil{, VTT Finland 

tu      20.8.                   - Plants                                 
                                Dr. Imad Saab, Univ of Illinois, USA 

we      21.8.                   - Plants                                 
                                Dr. Imad Saab (2 h) 
                                - Animal cells; an introduction 
                                Prof. Markku Kulomaa (2 h), Univ of Jyv{skyl{ 

th      22.8.                   Transcriptional mechanisms               
                                Dr. Robert Weinzierl, Imperial College, UK 

fr      23.8.                   Chromatin and gene expression    
                                Dr. Vrjan Wrange, Karolinska Institute 

mo      26.8.                   Protein glycosylation and  
                                Dr.Ineke Braakman, Univ of Amsterdam 

tu      27.8.                   Protein secretion in yeast;              
                                a genetic approach 
                                Dr. Sirkka Ker{nen, VTT, Finland 

we      28.8.                   Students' seminars 

th      29.8.                   Protein targeting signals in plants      
                                Dr. Jvrgen Denecke, Univ of York, UK 

fr      30.8.                   Protein targeting signals in mammals     
                                Dr. Annette Hille-Rehfeld 
                                Univ of Gottingen, Germany 

Every day 

* 9-13 (or 14)  Lectures 
* 13-14         Lunch 
* 14-17         Seminars, presentations and practicals 

Lab works 
Week 1: Transfer of a marker gene into plant tissues and transient 
expression analysis 
Week 2: Targeting of  avidin-MPR300 fusion protein in fibroblasts. 

Anita Mikkonen 
Department of Biological and 
Environmental Science 
University of Jyvaskyla 
P.O.Box 35, 40351 Jyvaskyla 
Phone +358/41/602285 
Fax   +358/41/602221 
E-mail: mikkonen at 

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