Importance of knowing tertiary structure
cbarrett at cse.ucsc.edu
Thu Jul 10 13:05:52 EST 1997
>On 9 Jul 1997, Christian Barrett wrote:
>> With this post I would like to generate a response from the community
>> about the impact of a successful computational method for determining
>> protein tertiary structure. I am interested in the scope of its
>> application; in how many (and which) different academic/industrial
>> research areas would it have a profound effect? And, what would this
>> effect be? Put another way, how would the world be changed?
>> Do you know of any reviews that address this question?
>This sounds a bit like an exam question to me. Do you have a real
>in this subject or are you looking for us to write an essay?
No, this is not an exam question. For the most part, I'm aware of the
importance of protein structure. But I don't know everything and
sometimes learn of new (to me) uses associated with knowing 3D structure.
For instance, last year I heard a talk by James Wells about minimizing
proteins. Because I don't work at Genetech or deal with making drugs
by protein engineering, I would have never thought about the need to
minimize a protein. And for this work, knowing the 3D structure was
fundamental. But to get the 3D structure after every redesign of the
protein required xray crystallography. So I see were an accurate
structure prediction method would have helped here (protein design
and saving time).
I've heard many times that the ability to predict a protein's structure
would amount to the greatest advance of our time in molecular biology.
Given all that is happening in the field these days, I was just looking
for some justification of this statement.
More information about the Bioforum