HB-EGF as a protooncogene???

[JB]

What=92s your opinion?

Recently we have discussed in our lab if growth =

factors like HB-EGF can be considered a =

protooncogenes.


To my opinion:  =


when considering the definition of a protooncogene is a gene =

involved in proliferation and differentiation pathways, and when =

mutated it causes in concert with other functionally related genes =

a cancer, then HB-EGF could be also considered a protooncogene.