To: David Konerding Re: The human genome - how is it distributed?

Ralph Gainey sesame at MCN.ORG
Mon Mar 31 23:46:20 EST 1997


Dear David,

I very much appreciate your posting this information and insight...

With warm regards,
Ralph Gainey


[David Konerding wrote]

>Genes are distributed on both strands.  A segment of DNA could be as such:
>
>5' >>>>>>>>>>>>>>>>>>>>>>::::::::::::::::::::::::::::::::: 3'
>3' ::::::::::::::::::::::::::::::<<<<<<<<<<<<<<<<<<<<<<<<< 5'
>
>Where : represents non-coding DNA and > and , represent coding DNA.
>
>As you may see, both strands contain coding DNA (genes).  The direction
>of coding depends on the strand- all genes on the top strand will code
>genes in one direction (left to right in this case) and genes in the
>bottom strand will code in the opposite direction.
>
>The E.Coli genome contains examples such as:
>
>::::::::::>>>>>>>>>>>>>>>>>>>:::::::::::::::::::::
>::::::::::::::::::::<<<<<<<<<<<<<:::::::::::::::::
>
>where two genes occupy the same DNA but opposite strands and run
>in opposite directions.  I've always been amazed at this sort of coding
>because it implies a certain co-evolution of the genes.   For example,
>since there are really only three start codons and three stop codons,
>there are only certain mutations which could occur in the amino acid
>coded for by the reverse complement of the start codon of a gene.




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