FINAL PROGRAMME - Chronic Viral Hepatitis Meeting
kay at lyon151.inserm.fr
Sat Sep 20 01:52:45 EST 1997
For information on the accompaning ICN Flavivirus Symposium (Lyon, 9th
October 1997) and for details of registration at the Chronic Viral Hepatitis
Meeting, please consult the dedicated web site at :
The final programme for the Vth International Conference "Current Trends in
Chronically Evolving Viral Hepatitis" is as follows:
Vth International Conference
Current Trends in Chronically Evolving Viral Hepatitis
10-11th October 1997
PALAIS DES CONGRÈS - LYON
Friday 10 October - Morning
08h15-08h30 Welcome : Christian TRÉPO
Opening : Sheila SCHERLOCK
Evolution of antiviral drugs : is there concordance between discovery and
08h30-10h30 First Session : Viral kinetics
The HCV quasispecies : biological and clinical implications
Uncovering the dynamics of HIV and HCV in vivo via mathematical
HCV kinetics : acute dose response to interferon
European study of induction IFN therapy for chronic HCV
HCV mutation during IFN therapy
The effect of pretreatment HCV quasispecies mutations on IFN reponse
Patricia PONTISSO (Martina GEROTTO)
HCV kinetics during HCV infections
Ultrarapid hepatitis C virus clearance by daily high dose Interferon in
nonresponders to standard therapy.
11h00-12h40 Second Session : Viral detection
Development and clinical applications of quantitative PCR assays
for HCV and HBV viral load determination
The use of PCR dependant algorithm for he management of patients
infected with HCV.
Juan I. ESTEBAN
HCV replication. Correlation between HCV RNA and HCV core antigen
Compartimentalisation of HCV genome : a new concept
Detection of hepatitis C virus RNA by in situ hybridization : a critical
Differences in hepatitis C virus quasispecies composition between liver,
peripheral blood mononuclear cells and plasma.
Klaus M. WEINBERGER
Sequence variability of the HBS-gene in chronic carriers of
hepatitis B virus (HBV) lacking serologically detectable HBSAG.
Hepatotropism of GB-C virus/HCV
12h40-14h00 LUNCH and POSTER VIEWING
Friday 10 October - Afternoon
14h00-15h50 Third Session : Immune response
Host immune responses in chronic HCV infection
Host immune responses in chronic HCV infection.
Association of virus specific helper T-cell response with viral clearance
in acute HCV infection
Cytotoxic T-cells in hepatitis C : analysis 20 years after an infection
with one strain of hepatitis C virus.
Cross-reactive and genotype specific T cell responses to the hepatitis C
virus in infected humans and immunized mice.
Lymphocyte reacivity to Hepatitis C virus antigens shows evidence for
exposure to hepatitis C virus in HCV-seronegative spouses of HCV-
Specific association of immune response to the HCV E1 protein with
hepatitis C disease activity
Mechanisms in the viral host interaction in hepatitis B virus infection
Costimulatory molecules in fulminant hepatic failure.
16h15-18h00 Fourth Session : New approaches for therapy
Immunotherapy of chronic hepatitis virus infection
Strategies for therapeutic vaccination of chronic hepadna virus infection
Host-virus interactions in HBV replication
Gene therapy for chronical viral hepatitis
Natural history of hepatitis C.
Kinetics and magnitude of Interferon-induced antiviral gene expression in
DNA mediated immunization elicits a protective immune response against
Evaluation of HCV E-2 envelope glycoprotein expressing plasmids in the
development of a DNA vaccine.
18h00-19h00 POSTER VIEWING
Saturday 11 October - Morning
08h15-10h20 Fifth Session : Public health therapy
Prevention and control of hepatitis C with interferon
Prevention of hepatitis C in Italy : lessons from surveillance of type
specific acute viral hepatitis
Epidemiology of hepatitis C infection in France
Hepatitis virus B vaccination results and antenatal transmission of HBV
markers to neonates
Ribavirin for the retreatment of HCV + patients non responder to
Risk factors and natural history of HCV related cirrhosis
The impact of HBV infection on the natural history and response to
interferon of chronic hepatitis C patients.
10h50-12h45 Sixth Session : Therapy
Mechanisms of interferon resistance in chronic HCV infection
The long-term course of IFN-treated patients with chronic hepatitis C
Renforced versus standard regimen of interferon alfa in chronic hepatitis
infection. Results of a multicentric randomized trial in 244 patients
Overcoming non-response at 3 months of interferon therapy
" HCV treatment " An audit of results of Interferon therapy for HCV in West
Sequential treatment of chronic hepatitis C with interferon and ribavirin
Predictors of response to Famciclovir treatment in chronic hepatitis B
Combination therapy in chronic hepatitis B
Nucleoside analogue and combination therapy of HBeAg negative chronic
Saturday 11 October - Afternoon
14h00-15h35 Seventh Session : New viruses and variants
An update on HDV infection and hepatitis D
Genetic comparison of GB virus C strains derived worldwide indicates an
extremely low rate of molecular evolution.
Michael MANNS/Dr HERINGLAKE
GBV-C and fulminant hepatic failure
Structural and functional complexity of HBV variants
Molecular strategies of hepadnavirus "quasispecies" adaptation to a new
Rapid detection of HBe Ag negative variants of HBV : influence of
in the promoter and the 1st Aug of the pre-C region on viral persistence.
Mutations in the hepatitis B virus polymerase gene during prolonged
lamivudine treatment : indications for the involvement of two mutations.
16h00-17h50 Eighth Session : Breakthroughs
Evidence for the involvement of two distinct tumor suppressor loci on
chromosome 8p in hepatocellular carcinoma by deletion mapping
Potential hepatocellular receptors for hepatitis B virus
Characterisation of HBV pre-S hepatocyte binding domains and a CD1a-
like cellular receptor using epitope libraries.
HCV-related lymphoproliferative disorders.
Ribavirin therapy shifts the T-Helper 1 (Th1)/Th2 subset balance in vivo.
Tree-shrews as an in vivo test tube for propagation of HCV infection
Petr. G. DERYABIN
HCV reproduction in primary cells cultures of suckling mouse brain
John VIERLING (with F. ZEYTIN)
Development of model systems in vitro and in vivo
Laboratories without walls : a novel design for creating an Interactive,
Multinational, and Mutlidisciplinary HCV research programme
17h50-18h00 Jean-Pierre BENHAMOU
"Virus des hepatites, retrovirus Humains et pathologies associees"
151 cours Albert Thomas, 69424 LYON CEDEX 03, FRANCE
e-mail : kay at lyon151.inserm.fr
tel : (33) 04 72 68 19 76
fax: (33) 04 72 68 19 71
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