New Book- Penicillin: A Paradigm for Biotechnology

Richard Mateles rmateles at candida.com
Wed Dec 16 15:07:34 EST 1998


Penicillin: A Paradigm for Biotechnology

Reprints "The History of Penicillin Production", the classic publication of
the American Institute of Chemical Engineers, originally published in 1970
and long out-of-print.   It is updated by the inclusion of two new chapters
dealing with scientific advances in penicillin biochemistry, microbiology,
and genetics made since 1970; and the current commercial and industrial
status of penicillin and its derivatives.

This book tells the remarkable story of penicillin’s progress from a
laboratory curiosity to being the first antibiotic available for regular
use, and still a very important product today.  The contributors to this
book are the scientists and engineers who played the major role in that
enterprise, which has served as a model for fermentation development for the
last fifty years.

Among the penicillin program’s "firsts,"  which continue to be important in
biotechnology today, were:

    mutation and selection for microbial strain improvement
    scale-up of fermentors for aerobic processes
    countercurrent liquid-liquid extraction
    industrial-scale lyophilization of sterile pharmaceuticals
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