jmone at MARAUDER.MILLERSV.EDU
Mon Jun 29 09:18:17 EST 1998
1. p24 protein is highly conserved among HIV isolates. It is also
very immunogenic. Virtually 100% of HIV infected individuals produce
antibodies against p24, which makes it a valuable diagnostic marker.
2. HIV exists in the body both as free virus and as intracellular
virus. In order to get a good appreciation of viral load, it is
important to assay both forms of virus.
3. Human lymphoblastoid cell lines such as CEM and Molt 4 are very
sensitive indicators of the presence of virus. Co-cultivation of
infected lymphocytes with one of these indicator cell lines rapidly
induced cytopathic effects. The target cell specificity of HIV appears
to change during the course of infection, from monocyte trophic to
lymphocyte trophic strains.
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