(none)

HC Harvey at TAMU.EDU
Fri Mar 6 17:00:51 EST 1998


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I need help on these questions
7.1:    Erythrose-4P is used in the biosynthesis of aromatic amino acids
(see LNS p704). Describe the pathway for the net synthesis of =
erythrose-4P
from glucose. What is the overall stoichiometry?

7.2:    The equilibrium constant for the NADP-linked oxidation of
glucose-6P to its delta-lactone is 1.2. Examine the structure of the
lactone ring. What structural property of the lactone makes it =
susceptible
to facile reduction by NADPH?

7.3:    The antimalarial drug Primaquine causes a decrease in =
glutathione
(GSH -- see p712) in erythrocytes (rbc).  GSH protects rbc by reacting =
with
peroxides (which may form oxygen and hydroxyl radicals and disrupt cell
membranes) and by reducing methemoglobin to hemoglobin (ie Fe+3 --> =
Fe+2).
GSH is generated by the enzyme glutathione reductase which uses NADPH as
cofactor.
a:      What effect will Primaquine have on the NADP/NADPH ratio in rbc?
b:      What effect will Primaquine have on glucose-6P dehydrogenase
activity in rbc?
c:      What effect will Primaquine have on the rate of the HMP pathway?
d:      What effect will Primaquine have on the life time of rbc?

7.4:    About 11% of African Americans have a deficiency of glucose-6P
dehydrogenase that can lead to hemolytic anemia. Explain why this =
occurs.

7.5:    Predict the effect of antimalarial drugs such as Primaquine on =
the
African American population with reduced glucose-6P dehydrogenase =
activity.

Harvey Castro
Founder of AMSA Premed at Texas A&M University
National Premedical Trustee of AMSA ( American Medical Student =
Association)
(Vote for me as your Texas Senator 2030)
Harveycas at juno.com after may1 98
...I shall be telling this with a sigh
Two roads diverged in a yellow wood
And I, I took the one less traveled
And that has made all the difference...
-- The Road Not Taken
   Robert Frost

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<DIV>I need help on these questions<BR>7.1:&nbsp;&nbsp;&nbsp; =
Erythrose-4P is=20
used in the biosynthesis of aromatic amino acids<BR>(see LNS p704). =
Describe the=20
pathway for the net synthesis of erythrose-4P<BR>from glucose. What is =
the=20
overall stoichiometry?<BR><BR>7.2:&nbsp;&nbsp;&nbsp; The equilibrium =
constant=20
for the NADP-linked oxidation of<BR>glucose-6P to its delta-lactone is =
1.2.=20
Examine the structure of the<BR>lactone ring. What structural property =
of the=20
lactone makes it susceptible<BR>to facile reduction by=20
NADPH?<BR><BR>7.3:&nbsp;&nbsp;&nbsp; The antimalarial drug Primaquine =
causes a=20
decrease in glutathione<BR>(GSH -- see p712) in erythrocytes =
(rbc).&nbsp; GSH=20
protects rbc by reacting with<BR>peroxides (which may form oxygen and =
hydroxyl=20
radicals and disrupt cell<BR>membranes) and by reducing methemoglobin to =

hemoglobin (ie Fe+3 --&gt; Fe+2).<BR>GSH is generated by the enzyme =
glutathione=20
reductase which uses NADPH =
as<BR>cofactor.<BR>a:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=20
What effect will Primaquine have on the NADP/NADPH ratio in=20
rbc?<BR>b:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; What effect will Primaquine =
have on=20
glucose-6P dehydrogenase<BR>activity in =
rbc?<BR>c:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=20
What effect will Primaquine have on the rate of the HMP=20
pathway?<BR>d:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; What effect will Primaquine =
have on=20
the life time of rbc?<BR><BR>7.4:&nbsp;&nbsp;&nbsp; About 11% of African =

Americans have a deficiency of glucose-6P<BR>dehydrogenase that can lead =
to=20
hemolytic anemia. Explain why this occurs.<BR><BR>7.5:&nbsp;&nbsp;&nbsp; =
Predict=20
the effect of antimalarial drugs such as Primaquine on the<BR>African =
American=20
population with reduced glucose-6P dehydrogenase =
activity.<BR>&nbsp;</DIV>
<DIV><FONT color=3D#000000 face=3D"Times New Roman">Harvey =
Castro<BR>Founder of AMSA=20
Premed at Texas A&amp;M University<BR>National Premedical Trustee of =
AMSA (=20
American Medical Student Association)<BR>(Vote for me as your Texas =
Senator=20
2030)<BR><A href=3D"mailto:Harveycas at juno.com">Harveycas at juno.com</A> =
after may1=20
98<BR>...I shall be telling this with a sigh<BR>Two roads diverged in a =
yellow=20
wood<BR>And I, I took the one less traveled<BR>And that has made all the =

difference...<BR>-- The Road Not Taken<BR>&nbsp;&nbsp; Robert=20
Frost</FONT>&nbsp;</DIV></BODY></HTML>

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