To the question of foundation of enterosorbtion therapy.

Dmitry Shin shindi at CHAT.RU
Sat Nov 28 07:22:57 EST 1998


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                       To the question of foundation of  enterosorbtion =
therapy.
Endogenous intoxication is unspecifical (by clinical and biochemical =
demonstration) syndrome of discrepancy of formation a hemolymph and =
raising of products of the normal interchange substances, and products =
of broken  metabolism.
Conception of endogenous intoxication  is  the reflection of =
disturbances of  microcirculation of hemolymph, rheology, gaseouse =
exchange and oxigen reservation; immunity  and anti-infectious =
protection and conducting of embodiment of this active conditions.
 There are different kinds of  markers of endogenouse intoxication. =
These are biochemical (hypoxia and acidose, the level of  =
middlemolecular oligopeptides, of ammonia,  of aminoacids, of bilirubin, =
toxic enzyme patology, etc.), immulogical (including exponents, which =
reflects quantitative correlation of immunocytes, theirs uncional =
activity, adequacy of regulation mechanism  of  immunological answering =
and specifical components of immunocytes activity) and integral marker =
of endogenous intoxication. Intergal markers are clinical demonstrations =
(adinamia, apathy, asthenia, broking of memory, of  sleep, irritability, =
anorexy),  toxility of the internal circumstances, cardiac disturbance, =
disturbance of central hemodynamic and bioelectrical activity of brains, =
condition of  confession, intellect, bichaviour, presense of  =
nerve-muscle disorders and etc. So demonstrations of toxicosis exists =
practically during all the acute infectional and uninfectional deseases =
and  chronicals, especially in the period of worsening.
 During the struggle with endogenious intoxication methods of phisicaly =
and chemical detoxication taking an important place.  Methods of =
enterosorbtion are the best for clinical using.=20
=E5=C8=C5=D2=D4 convinience avialability orally taken sorbents, it =
connected with the great role of the alimentary canal in transport and =
distributing of toxines and metabolites. Alimentary canal ensures =
transfer of toxines, bacterias and another substances through =
biomembranes at the expence of concetration and osmotic gradients by =
absorption or washing out them from the lymph, from the blood, from the =
digestive canal.=20
Besides it, digestive canal is the  vicarious  organ of transport and =
distributing of  urea, creatinine: all the lenght of small intestine can =
concetrate and move off 33 gr. Of urea, 14% of the total creatinine, 5% =
of ammonia and another toxines. Digestive canal accomplishes  transport =
and distributing of biologically active substances, sanitating large =
intestine, regulate transport of antigens, albumen, peptides, takingpart =
in theblocal and system immunological answer.  =20
Liver-intestine circulation of gall acides accomplishes intestine =
cenosis, keeping natural mechanism of neutralization of bacterial =
liposaccharides.
In the present time many preparations, which realizes tying of =
substances in the digestive canal, by absorbtion, adsorbtion, ionite and =
complexing can be used for the  entersorbtion. Orally taken sorbents =
with the wide srectrum of absorbent activity realizes gastrointestinal =
detoxication by such mechanismes, as:
-Adsorbtion and elimination of toxic substances of pathgenic organisms, =
occured to the alimentary canal from outside;
-Absorbtion and moving off toxines, appeared in the gleam of intestine =
as the result of their massive transfer throught biomembranes at the =
expence of concetration and osmotic gradients between lymph, blood and =
contence of alimentary canal;
-Cleaning before back suction of digestive liquid, made in the =
alimentary canal, which including, as lymph does, a great quantity of =
digestive liquids. Cleaning of  this liquids, produsing by the digestive =
canal in a big volume (6-9 liters a day in an adult organism) blockade =
one of the most important canals of recirculation  of toxic substances;
-Moving off toxic substances, generated in the alimentary ( indoles, =
phenoles, mercaptans, boiactive intestine polipeptides, and toxines in =
the bacterial form) what decreases functional commitment  to the liver =
and allows to utilize it's detoxicational potential;
-strengthening of transferof bioacive substances (for exmple gall =
acides), which have a good influence to the cavity digestion from the =
high portions of digestive;
-modification of  lipid and aminoacide spectrum of  alimentary contence =
at the exepence of  preferential abcorption of aromatic aminoacides, =
free fat acides, etc.
POLISORB MP, which prodused by the POLISORB Company can be a good =
example of an entersorbent of the new generation, having not only =
sorbtion behaviours.  =20

Looks  like a light blue-and- white powder.Has no smell and taste.=20

Polisorb can be used in monotherapy and in complex with others =
preparations. In the last way it doesn't sorb that preparations, but =
prolong and increases theirs effects.
During applique work Polisorb has a reducing and wound-heal effect. =
During suppurative inflammations averts growing of progressively worse =
of necrotic exchanges. Promotes tearing away of lacking vitality =
tissues, supplies with active decontomination, detoxication of centre of =
the lesion and of the whole organism. Reduces adherence of the wound =
bandage, increases sencebility of wound microflora to antibiotics, =
impedes to diffusion of toxines to the tissues and curtails the time of =
treatment.  =20
Entersorbtion during taking Polisorb per os gives a clear detxicational =
effect during viral hepatitus, acute and respiratory viral infections, =
renal unsuficiency. Polisorb can be used for the treatment of every =
kinds of poisoning , including poisoning with mushrooms, drugs, alcohol =
and during botulism; in the case of diarrhea in every genesis, allergy =
deseases. Polisorb normalizes the level of bilirubin and cholesterol in =
blood, makes a good influence during extensive polyarthritis, =
atherosclerosis, myocardial infarction in acute form, and others =
deseases, with following toxicosis.
Polisorb moves radionuclide and salts of heavy metalls off from =
organism, preventing theirs adverse influence to the organism.Polisorb =
can be used in prophylactic aim.

 POLISORB MP is an enterosorbent made on the base of  superfine silica, =
it has strongly pronounced universal sorbtion behaviour. This =
preparation sorbs microorganisms, endogenous and exogenous toxic =
substances of different origin, (including products of  exchanging of =
substances from the alimentary canal), microbe toxines, food allergens, =
medicinal preparations and poisons. Looks like white powder (or white =
powder with blue tint).

Indications to use.
This preparation should be used by adults as an enterosorbent during the =
acute intestinal infection, food toxicoinfections, food allergy, and =
different endogenous and exogenous intoxication, including acute =
poisoning with drastic drugs and virulent poisons,(including ethyl =
achogol).

Spillover functions.
Can be founded a deterioration of treatment effect of the medicines, =
taking at the same time with POLISORB MP.

Contraindications.
The relative contraindication are the ulrecative disease of the stomach =
and the duodenal ulcer in the acute form.
The =EDinistry of  the Healthkeeping and the Medical Industry of  =
Russia.=20
Approved by Pharmacological
Comitee on the 28th of October.
Instruction sheet
POLISORB MP.
The registration number is 965011

Dmitry Shin
shindi at chat.ru , ICQ 11080615 (AR)

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<DIV>
<DIV>
<DIV>
<DIV>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=20
To the question of foundation of&nbsp; enterosorbtion =
therapy.<BR>Endogenous=20
intoxication is unspecifical (by clinical and biochemical demonstration) =

syndrome of discrepancy of formation a hemolymph and raising of products =
of the=20
normal interchange substances, and products of broken&nbsp;=20
metabolism.<BR>Conception of endogenous intoxication&nbsp; is&nbsp; the=20
reflection of disturbances of&nbsp; microcirculation of hemolymph, =
rheology,=20
gaseouse exchange and oxigen reservation; immunity&nbsp; and =
anti-infectious=20
protection and conducting of embodiment of this active=20
conditions.<BR>&nbsp;There are different kinds of&nbsp; markers of =
endogenouse=20
intoxication. These are biochemical (hypoxia and acidose, the level =
of&nbsp;=20
middlemolecular oligopeptides, of ammonia,&nbsp; of aminoacids, of =
bilirubin,=20
toxic enzyme patology, etc.), immulogical (including exponents, which =
reflects=20
quantitative correlation of immunocytes, theirs uncional activity, =
adequacy of=20
regulation mechanism&nbsp; of&nbsp; immunological answering and =
specifical=20
components of immunocytes activity) and integral marker of endogenous=20
intoxication. Intergal markers are clinical demonstrations (adinamia, =
apathy,=20
asthenia, broking of memory, of&nbsp; sleep, irritability, =
anorexy),&nbsp;=20
toxility of the internal circumstances, cardiac disturbance, disturbance =
of=20
central hemodynamic and bioelectrical activity of brains, condition =
of&nbsp;=20
confession, intellect, bichaviour, presense of&nbsp; nerve-muscle =
disorders and=20
etc. So demonstrations of toxicosis exists practically during all the =
acute=20
infectional and uninfectional deseases and&nbsp; chronicals, especially =
in the=20
period of worsening.<BR>&nbsp;During the struggle with endogenious =
intoxication=20
methods of phisicaly and chemical detoxication taking an important =
place.&nbsp;=20
Methods of enterosorbtion are the best for clinical using. =
<BR>=E5=C8=C5=D2=D4 convinience=20
avialability orally taken sorbents, it connected with the great role of =
the=20
alimentary canal in transport and distributing of toxines and =
metabolites.=20
Alimentary canal ensures transfer of toxines, bacterias and another =
substances=20
through biomembranes at the expence of concetration and osmotic =
gradients by=20
absorption or washing out them from the lymph, from the blood, from the=20
digestive canal. <BR>Besides it, digestive canal is the&nbsp; =
vicarious&nbsp;=20
organ of transport and distributing of&nbsp; urea, creatinine: all the =
lenght of=20
small intestine can concetrate and move off 33 gr. Of urea, 14% of the =
total=20
creatinine, 5% of ammonia and another toxines. Digestive canal=20
accomplishes&nbsp; transport and distributing of biologically active =
substances,=20
sanitating large intestine, regulate transport of antigens, albumen, =
peptides,=20
takingpart in theblocal and system immunological answer.&nbsp;&nbsp;=20
<BR>Liver-intestine circulation of gall acides accomplishes intestine =
cenosis,=20
keeping natural mechanism of neutralization of bacterial =
liposaccharides.<BR>In=20
the present time many preparations, which realizes tying of substances =
in the=20
digestive canal, by absorbtion, adsorbtion, ionite and complexing can be =
used=20
for the&nbsp; entersorbtion. Orally taken sorbents with the wide =
srectrum of=20
absorbent activity realizes gastrointestinal detoxication by such =
mechanismes,=20
as:<BR>-Adsorbtion and elimination of toxic substances of pathgenic =
organisms,=20
occured to the alimentary canal from outside;<BR>-Absorbtion and moving =
off=20
toxines, appeared in the gleam of intestine as the result of their =
massive=20
transfer throught biomembranes at the expence of concetration and =
osmotic=20
gradients between lymph, blood and contence of alimentary =
canal;<BR>-Cleaning=20
before back suction of digestive liquid, made in the alimentary canal, =
which=20
including, as lymph does, a great quantity of digestive liquids. =
Cleaning=20
of&nbsp; this liquids, produsing by the digestive canal in a big volume =
(6-9=20
liters a day in an adult organism) blockade one of the most important =
canals of=20
recirculation&nbsp; of toxic substances;<BR>-Moving off toxic =
substances,=20
generated in the alimentary ( indoles, phenoles, mercaptans, boiactive =
intestine=20
polipeptides, and toxines in the bacterial form) what decreases =
functional=20
commitment&nbsp; to the liver and allows to utilize it&rsquo;s =
detoxicational=20
potential;<BR>-strengthening of transferof bioacive substances (for =
exmple gall=20
acides), which have a good influence to the cavity digestion from the =
high=20
portions of digestive;<BR>-modification of&nbsp; lipid and aminoacide =
spectrum=20
of&nbsp; alimentary contence at the exepence of&nbsp; preferential =
abcorption of=20
aromatic aminoacides, free fat acides, etc.<BR>POLISORB MP, which =
prodused by=20
the POLISORB Company can be a good example of an entersorbent of the new =

generation, having not only sorbtion behaviours.&nbsp;&nbsp; </DIV>
<DIV>&nbsp;</DIV>
<DIV>Looks&nbsp; like a light blue-and- white powder.Has no smell and =
taste.=20
<BR></DIV>
<DIV>Polisorb can be used in monotherapy and in complex with others=20
preparations. In the last way it doesn&rsquo;t sorb that preparations, =
but=20
prolong and increases theirs effects.<BR>During applique work Polisorb =
has a=20
reducing and wound-heal effect. During suppurative inflammations averts =
growing=20
of progressively worse of necrotic exchanges. Promotes tearing away of =
lacking=20
vitality tissues, supplies with active decontomination, detoxication of =
centre=20
of the lesion and of the whole organism. Reduces adherence of the wound =
bandage,=20
increases sencebility of wound microflora to antibiotics, impedes to =
diffusion=20
of toxines to the tissues and curtails the time of =
treatment.&nbsp;&nbsp;=20
<BR>Entersorbtion during taking Polisorb per os gives a clear =
detxicational=20
effect during viral hepatitus, acute and respiratory viral infections, =
renal=20
unsuficiency. Polisorb can be used for the treatment of every kinds of =
poisoning=20
, including poisoning with mushrooms, drugs, alcohol and during =
botulism; in the=20
case of diarrhea in every genesis, allergy deseases. Polisorb normalizes =
the=20
level of bilirubin and cholesterol in blood, makes a good influence =
during=20
extensive polyarthritis, atherosclerosis, myocardial infarction in acute =
form,=20
and others deseases, with following toxicosis.<BR>Polisorb moves =
radionuclide=20
and salts of heavy metalls off from organism, preventing theirs adverse=20
influence to the organism.Polisorb can be used in prophylactic=20
aim.<BR></DIV></DIV>
<DIV>&nbsp;POLISORB MP is an enterosorbent made on the base of&nbsp; =
superfine=20
silica, it has strongly pronounced universal sorbtion behaviour. This=20
preparation sorbs microorganisms, endogenous and exogenous toxic =
substances of=20
different origin, (including products of&nbsp; exchanging of substances =
from the=20
alimentary canal), microbe toxines, food allergens, medicinal =
preparations and=20
poisons. Looks like white powder (or white powder with blue tint).</DIV>
<DIV>&nbsp;</DIV>
<DIV>Indications to use.</DIV>
<DIV>This preparation should be used by adults as an enterosorbent =
during the=20
acute intestinal infection, food toxicoinfections, food allergy, and =
different=20
endogenous and exogenous intoxication, including acute poisoning with =
drastic=20
drugs and virulent poisons,(including ethyl achogol).</DIV>
<DIV>&nbsp;</DIV>
<DIV>Spillover functions.<BR>Can be founded a deterioration of treatment =
effect=20
of the medicines, taking at the same time with POLISORB MP.<BR></DIV>
<DIV>Contraindications.<BR>The relative contraindication are the =
ulrecative=20
disease of the stomach and the duodenal ulcer in the acute form.<BR>The =
=EDinistry=20
of&nbsp; the Healthkeeping and the Medical Industry of&nbsp; Russia.=20
<DIV>Approved by Pharmacological<BR>Comitee on the 28th of =
October.</DIV>
<DIV>Instruction sheet<BR>POLISORB MP.</DIV>
<DIV>The registration number is 965011<BR></DIV></DIV></DIV>
<DIV><FONT color=3D#000000 face=3D"Arial Cyr" size=3D2>Dmitry =
Shin</FONT></DIV>
<DIV><FONT color=3D#000000 face=3D"Arial Cyr" size=3D2><A=20
href=3D"mailto:shindi at chat.ru">shindi at chat.ru</A> , ICQ 11080615=20
(AR)</FONT></DIV></DIV></DIV></BODY></HTML>

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