SYSTEM-LEVEL GENETIC CODES: AN EXPLANATION FOR BIOLOGICAL COMPLEXITY

taguebwREMOVE at wfu.edu taguebwREMOVE at wfu.edu
Mon Feb 28 08:21:33 EST 2000


A "system level genetic code" is not needed to (co)evolve complex
biological pathways. 

Check out Rutherford and Lindquist. (1998) "HSP90 as a capacitor for
morphological evolution." NATURE 396:336-342.


In article <896kc4$a9l$1 at sun500.nas.nasa.gov>, "John F. McGowan, Ph.D."
<jmcgowan at mail.arc.nasa.gov> wrote:

> SYSTEM-LEVEL GENETIC CODES: AN EXPLANATION FOR BIOLOGICAL COMPLEXITY
> 
> By John F. McGowan, Ph.D.
> Desktop Video Expert Center
> NASA Ames Research Center
> Mail Stop 233-18
> Moffett Field, CA 94035-1000
> E-Mail: jmcgowan at mail.arc.nasa.gov
> Telephone: (650) 604-0143
> 
> (2/24/00 2:41 PM)
> 
> ABSTRACT
> 
> Complex systems with tightly coadapted parts frequently appear in living
> systems and are difficult to account for through Darwinian evolution, that
> is random variation and natural selection, if the constituent parts are
> independently coded in the genetic code.  If the parts are independently
> coded, multiple simultaneous mutations appear necessary to create or modify
> these systems.  It is generally believed that most proteins are
> independently coded.  The textbook rule is one gene for one enzyme.  Thus,
> biochemical systems with tightly coadapted parts such as the blood clotting
> cascade pose a difficulty for Darwinian evolution.  This problem can be
> overcome if the current understanding of the genetic code is incomplete and
> a system-level genetic code in which seemingly independent proteins are
> encoded in an interdependent, highly correlated manner exists.  The methods
> by which human beings design and fabricate complex systems of tightly
> coadapted parts are explored for insights into the requirements for a
> system-level genetic code.  Detailed examples of system-level codes for
> networks of matching parts are presented.  The implications of identifying
> and deciphering the system-level genetic code if it exists for the
> prevention, treatment, and cure of heart disease, cancer, immune disorders,
> and for rational drug design are discussed.
> 
> http://www.jmcgowan.com/Complex.pdf

-- 
My 2 electrons,

Brian

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