protein which stops translation

Nick Theodorakis nicholas_theodorakis at urmc.rochester.edu
Tue Jun 27 16:59:46 EST 2000


Carlos Ribeiro <Carlos.Ribeiro at unibas.ch> wrote:
>Hello out there!
>
>Does anyone know of a protein which stops translation and which
could be
>used to stop translation by inducing it? As an alternative to
>cyclohexamyde!
>

It depends on what you mean by "inducing" it.

Ricin inhibits translation by modifying rRNA.

There's a poliovirus protein (don't remember the name, sorry)
that
inactivates the cap-binding protein. Does viral infection count
as
"inducing?"

I suppose if you can generate a constitutively active eIF2 kinase
that might work, too.


Nick Theodorakis

nicholas_theodorakis at urmc.rochester.edu
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