[Bioforum] Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences.

scimedweb from mail.com via bioforum%40net.bio.net (by scimedweb from mail.com)
Tue Jan 20 04:51:11 EST 2009


Comparative clinical and transcriptomal profiles of breast cancer
between French and South Mediterranean patients show minor but
significative biological differences.

by Nasséra Chalabi, Dominique J. Bernard-Gallon, Yves-Jean Bignon;
Breast Med Consortium, Fabrice Kwiatkowski, Marie Agier, Véronique
Vidal, Valérie Laplace-Chabaud, Valérie Sylvain-Vidal, Vincent
Bertholet, Françoise De Longueville, Marc Lacroix(*), Guy Leclercq,
José Remacle, Catherine Sibille, Nathalie Zammateo, Noureddine Ben
Jaafar, Abdelaziz Sefiani, Karim Ouldim, André Mégarbané, Nadine
Jalkh, Wejdène Mahfoudh, Wafa Troudi, Amel Ben Ammar-El Gaïed, Lotfi,
Chouchane

in Cancer Genomics & Proteomics (2008) 5, 253-261

(*) current affiliation of Marc Lacroix: InTextoResearch, Baelen
(Wallonia), Belgium


BACKGROUND: In Western countries, breast cancer incidence and
mortality are higher than in Mediterranean countries. These
differences have been ascribed to environmental factors but also to
late-stage diagnostic and biological specific characteristics.
PATIENTS AND METHODS: Between September 2002 and September 2005, we
collected clinical data by phone counselling 180 French and
Mediterranean breast cancer patients and performed microarray
experiments. RESULTS: Characteristics of breast cancer in patients
from Lebanon, Tunisia and Morocco were more aggressive (more SBR grade
III and positive node invasion) and patients were 10 years younger at
diagnosis. Sixteen differentially expressed genes such as MMP9, VEGF,
PHB1, BRCA1, TFAP2C, GJA1 and TFF1 were also found. Additionally, an
up-regulation of cytokeratins KRT8 and KRT18 may indicate a luminal B
subtype in "South" (Lebanon, Tunisia and Morocco) tumors while
"North" (France) tumors may more frequently be luminal A type.
CONCLUSION: This study allowed the identification of specific clinical
and transcriptomic parameters in patients from South Mediterranean
countries.



More information about the Bioforum mailing list