In defense of the Genome Boondoggle

Keith Elliston elliston at av8tr.UUCP
Fri Feb 15 13:31:31 EST 1991

In article <2054 at>, toms at (Tom Schneider) writes:

> And if you are going to poo-pa
> theoretical understanding, then I have some papers for you to read!  Start
> with:
> author = "G. D. Stormo
>  and T. D. Schneider
>  and L. Gold
>  and A. Ehrenfeucht",
> title = "Use of the `Perceptron' algorithm to distinguish translational
> initiation sites in {E. coli.}",
> year = "1982",
> journal = "Nucl. Acids Res.",
> volume = "10",
> pages = "2997-3011"}
> author = "L. Gold
>  and D. Pribnow
>  and T. Schneider
>  and S. Shinedling
>  and B. S. Singer
>  and G. Stormo",
> title = "Translational initiation in prokaryotes.",
> year = "1981",
> journal = "Annu. Rev. Microbiol.",
> volume = "35",
> pages = "365-403"}
> author = "G. D. Stormo
>  and T. D. Schneider
>  and L. M. Gold",
> title = "Characterization of translational initiation sites
> in {{E. coli.}}",
> year = "1982",
> journal = "Nucl. Acids Res.",
> volume = "10",
> pages = "2971-2996"}
> author = "T. D. Schneider
>  and G. D. Stormo
>  and L. Gold
>  and A. Ehrenfeucht",
> title = "Information content of binding sites on nucleotide
> sequences",
> year = "1986",
> journal = "J. Mol. Biol.",
> volume = "188",
> pages = "415-431"}
> author = "T. D. Schneider
>  and G. D. Stormo",
> title = "Excess Information at Bacteriophage {T7} Genomic Promoters
> Detected by a Random Cloning Technique",
> year = "1989",
> journal = "Nucl. Acids Res.",
> volume = "17",
> pages = "659-674"}

Nice C.V. Tom....   

Not be pick nits or anything, but this discussion seems to be going over
board.  Perhaps it is time to drop the dueling keyboards for a moment, and
spend some time in the thought process.  I would dearly love to see a sort
of debate go on on this subject (genome sequencing), but would like to suggest
a more refined type of discussion.  Perhaps we could have an address by
the proponents of the genome sequence initiative, formulated collectively
by a group via e-mail.  We could then also have an address by a group
that is against the genome initiative, again collectively written by 
a group.  This might reduce the flaming, and bring us all to a more in-depth
understanding of the issues from both sides.  We could then discuss the
issues that are disparate and not have to be reduced to singular views
or flaming wars.

I suspect that a large number of the people reading these messages are like
me.... in that I see many advantages to genome sequencing, but also quite
a few shortcomings/disadvantes as well.

So... who wants to be the head of the Pro Genome sequencing group (Tom??)
How about the Anti Genome sequencing group? (Did I hear a woof.. or was
it a non-woof?)


Keith "where did Rob Harper go?" Elliston
elliston at

... inews fodder .....


Keith O. Elliston          elliston at av8tr.UUCP           elliston at
AA5A N9734U                elliston at     elliston at biovax.bitnet

"Fly because you have to, to keep some semblance of sanity."

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