DOE Guman Genome Program Notices

stodolsk at oerv01.er.doe.gov stodolsk at oerv01.er.doe.gov
Tue Apr 28 09:13:49 EST 1992


NOTICEs requesting research proposals supporting the Human Genome
Program of the US Department of Energy are presented below. 
Please specifically note the following:

      1. In the area of Chromosome Mapping and DNA
      Sequencing, the focus is on systems automation and
      supporting instrumentation.  Applications focused
      solely on the development of new biological and
      biochemical resources are not requested.  Applications
      in the area of Informatics are specifically sought.  

      2. Preapplications a few pages in length are sought by
      June 15, 1992, to permit a timely response on the
      relevance of the proposed research by Human Genome
      Task Group Staff.  

      3. Preprosals can also be sent by electronic mail
      through the Internet system to:           
      genome at er.doe.gov 

      4. The deadline for receipt of formal Applications is
      August 7, 1993.

There is a separate NOTICE requesting proposals on Ethical Legal
and Social Issues (ELSI) related to the Human Genome Program.


==============================================================
Department of Energy
Office of Energy Research
Special Research Grant Program Notice 92-13:  Human Genome Program
- Technological Advances

ACTION:  Notice inviting grant applications.

SUMMARY:  The Office of Health and Environmental Research (OHER)
of the Office of Energy Research (ER), U.S. Department of Energy
hereby announces its interest in receiving applications for
Special Research Grants in support of the Human Genome Program. 
This Program is a coordinated multidisciplinary research effort
aimed at developing creative, innovative resources and
technologies which will lead to a detailed understanding of the
human genome at the molecular level.  Several research goals are
encompassed in this notice:  (1) Research will be supported for
development and implementation of automated chromosome mapping
technologies and advanced DNA sequencing technologies,
specifically, innovative instrumentation and automated systems
that offer the potential for rapid, cost-effective sequencing of a
million bases per day, which includes non-gel techniques and
direct imaging approaches; (2) Research will be supported to
develop software for applied genome informatics for use in DNA
mapping and sequencing.  Such work includes information retrieval,
user interfaces including interfaces compatible with Genome Data
Base (GDB), databases, communications, algorithms, software
engineering, and data management.  Also desired are improved
algorithms and hardware for analyzing DNA sequences, including
identification of homologies, regulatory sites, and protein coding
regions.

Before preparing a formal application, potential applicants are
encouraged to submit a brief preapplication in accordance with 10
CFR 600.10(d)(2), which consists of two to three pages of
narrative describing the research project objectives and methods
of accomplishment.  These will be reviewed relative to the scope
and research needs of the DOE Human Genome Program. 
Preapplications referencing Program Notice 92-13 should be
received by June 15, 1992, and sent to Dr. David A. Smith, Office
of Health and Environmental Research, 
ER-72 (GTN), Washington, D.C. 20585, (301) 903-6488.  Telephone
and telefax numbers are required parts of the preapplication.  A
response to the preapplications discussing the potential program
relevance of a formal application generally will be communicated
within 30 days of receipt.

DATES:  Formal applications submitted in response to this notice
must be received by 4:30 p.m., E.D.T., August 7, 1992, to be
accepted for merit review in October 1992 and to permit timely
consideration for award in Fiscal Year 1993. 

ADDRESS:  Formal applications referencing Program Notice 92-13
should be forwarded to:  U.S. Department of Energy, Office of
Energy Research, Acquisition and Assistance Management Division,
ER-64, Room G-236, Washington, D.C. 20585, ATTN: Program Notice
92-13.  The following address must be used when submitting
applications by U.S. Postal Service Express, any commercial mail
delivery service, or when handcarried by the applicant:  U.S.
Department of Energy, Acquisition and Assistance Management
Division, ER-64, 19901 Germantown Road, Germantown, MD  20874.

FOR FURTHER INFORMATION CONTACT:  Dr. David A. Smith, Office of
Health and Environmental Research, ER-72 (GTN), Office of Energy
Research, U. S. Department of Energy, Washington, D.C.  20585, 
(301) 903-6488. 

SUPPLEMENTARY INFORMATION:  It is anticipated that approximately
$2.2 M will be available for grant awards during FY 1993,
contingent upon availability of appropriated funds.  Multiple year
funding of grant awards is expected, and is also contingent upon
availability of funds.  Previous awards have ranged from $79
thousand per year up to $1 million per year (total costs) with
terms from 1 to 3 years.  Most awards are in the $200 thousand to
$400 thousand per year (total costs) range for 3 years.  Similar
award sizes are anticipated for new grants.  Information about
development and submission of applications, eligibility,
limitations, evaluation, selection process, and other policies and
procedures may be found in the ER Application and Guide for the
Special Research Grants Program and 10 CFR Part 605.  The OER, as
part of its grant regulations, requires at 10 CFR 605.11(b) that a
grantee funded by OER and performing research involving
recombinant DNA molecules and/or organisms and viruses containing
recombinant DNA molecules shall comply with the National
Institutes of Health "Guidelines for Research Involving
Recombinant DNA Molecules" (51 FR 16958, May 7, 1986), or such
later revision of those guidelines as may be published in the
Federal Register.  The dissemination of materials and research
data in a timely manner is essential for progress towards the
goals of the DOE Human Genome Program.  OHER requires the timely
sharing of resources and data.  Applicants should, in their
applications, discuss their plans for disseminating research data
and materials which may include, where appropriate, putting cell
lines, probes, sequence data, etc., into public repositories. 
Funds to defray the costs of disseminating materials or submitting
data to repositories are allowable; however, such requests must be
adequately justified.  

The application kit and guide is available from the U.S.
Department of Energy, Acquisition and Assistance Management
Division, Office of Energy Research, ER-64, Washington, D.C. 
20585.  Telephone requests may be made by calling (301) 903-6488
or FTS (301) 903-6488.  Instructions for preparation of an
application are included in the application kit.  The Catalog of
Federal Domestic Assistance Number for this program is 81.049.

Issued in Washington, D.C. on April, 24 1992.


D. D. Mayhew
Deputy Director for Management 
Office of Energy Research

=============================================================

The NOTICE for ELSI Applications follows, with the same preprosal
and formal Application dates as above.

--------------------------------------------------------------

Department of Energy
Office of Energy Research
Special Research Grant Program Notice 92-14:  Human Genome Program
- Ethical, Legal, and Social Issues

ACTION:  Notice inviting grant applications

SUMMARY:  The Office of Health and Environmental Research (OHER)
of the Office of Energy Research (ER), U.S. Department of Energy,
hereby announces its interest in receiving applications for
Special Research Grants in support of the Ethical, Legal, and
Social Issues (ELSI) activities of the Human Genome Program (HGP). 
This Program is a coordinated multidisciplinary research effort
aimed at developing creative, innovative resources and
technologies which will lead to a detailed understanding of the
human genome at the molecular level.  This particular research
notice encompasses research and conference grants that address
ethical, legal, and social issues that may arise from applications
of knowledge and materials resulting from the HGP.  The DOE
especially encourages the submission of applications to conduct
multidisciplinary empirical research in the area of privacy as it
pertains to genetic information.  This may include (but is not
limited to) issues of ownership and control of genetic
information, consent to disclosure and use of genetic information,
the impact on scientific collaboration and candor, and the role(s)
of high performance computers in information management relevant
to genetic data.  Applications should demonstrate awareness of the
relevant literature, and should include detailed plans for the
development and analysis of factual information and the conduct of
normative inquiry bearing on the ethical, legal, and social issues
presented by applications of the knowledge gained from the HGP. 
All applications should include, where appropriate, detailed
discussion of human subjects protection issues; e.g., storage of,
manipulation of, and access to data.  Where survey techniques are
proposed, inclusion of women, minorities, and potentially disabled
individuals must be noted and described, unless specific
exclusions are scientifically necessary and justified in detail.  

The DOE is also soliciting applications for the preparation and
dissemination of educational materials in any appropriate medium
that will enhance public understanding of both the scientific
aspects and the ethical, legal, and social aspects of the HGP.  In
addition, DOE is encouraging conferences focusing on specific
issues or areas of concern related to the ethical, legal, and
social implications of the HGP.  Educational and conference
applications should also demonstrate awareness of the relevant
literature, and include detailed plans for the accomplishment of
project goals.  In the case of educational activities, the DOE
strongly recommends inclusion of assessments of effectiveness of
the proposed activities.  In the case of conferences, a fairly
detailed and complete roster of committed speakers is necessary. 
At the completion of the conference, a summary or report is
required.

Before preparing a formal application, potential applicants are
strongly encouraged to submit a preapplication in accordance with
10 CFR 600.10(d)(2), which consists of two to three pages of
narrative describing research objectives, methods of
accomplishment, measures of accomplishment including anticipated
products, and an estimated budget.  These will be reviewed
relative to the scope and the research needs of the DOE's Human
Genome Program ELSI activities.  Preapplications referencing
Program Notice 92-14 should be received by June 15, 1992, and sent
to Dr. Daniel W. Drell, Office of Health and Environmental
Research, ER-72 (GTN), U.S. Department of Energy, Washington, D.C. 
20585.  Telephone and FAX numbers are required parts of the
preapplication.  A


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