Marvin.Stodolsky%er-04 at Marvin.Stodolsky%er-04 at
Fri Feb 26 17:11:42 EST 1993

Note in SUPPLEMENTARY INFORMATION that the preapplication 
deadline date is April 15, 1993.  Application Kits for formal
proposals will be returned with DOE/OHER responses to the 
preapplications.  Preapplications can be submitted by email
with hardcopy sent by US mail, 

preferably to:

      #genome%er. at

or alternatively to

      genome at

from the Federal Register Volume 58, Issue 30, pg 8746

Department of Energy
Office of Energy Research
Energy Research Financial Assistance Program Notice 93-12:  
      Human Genome Program - Technological Advances
AGENCY:  Department of Energy (DOE)
ACTION:  Notice inviting grant applications.

SUMMARY:  The Office of Health and Environmental Research (OHER)
of the Office of Energy Research (ER), U.S. Department of Energy
(DOE) hereby announces its interest in receiving applications in
support of the Human Genome Program.  This Program is a
coordinated, multidisciplinary, goal oriented, research effort
aimed at developing creative, innovative resources and
technologies which will lead to a detailed understanding of the
human genome at the molecular level.  Several research goals are
encompassed in this notice, with collaborative, multidisciplinary
efforts specifically encouraged.  Research will be supported:  (1)
for development and implementation of mapping resources, cross
connecting distinct DNA clone libraries, mapping strategies and
automated mapping instrumentation; (2) for advanced DNA sequencing
technologies, specifically, innovative instrumentation and
automated systems that offer the potential for rapid, cost-
effective, large-scale sequencing; and (3) to develop software for
use in chromosome mapping and DNA sequencing, and data analysis. 
Such work may include information retrieval, user interfaces
including interfaces compatible with Genome Data Base (GDB),
algorithms, software engineering, and data management.  Also
desired are improved computational resources for analyzing DNA
sequences, including identification of homologies, regulatory
sites, and protein coding regions.

DATES:  Formal applications submitted in response to this notice
must be received by 4:30 p.m., E.D.T., July 15, 1993, to be
accepted for merit review in September 1993, and to permit timely
consideration for award in Fiscal Year 1994. 

ADDRESS:  Formal applications referencing Program Notice 93-12
should be forwarded to:  U.S. Department of Energy, Office of
Energy Research, Acquisition and Assistance Management Division,
ER-64, Washington, D.C. 20585, ATTN:  Program Notice 93-12.  The
following address must be used when submitting applications by
U.S. Postal Service Express Mail or any commercial mail delivery
service, or when handcarried by the applicant:  U.S. Department of
Energy, Acquisition and Assistance Management Division, ER-64,
19901 Germantown Road, Germantown, MD  20874.

Health and Environmental Research, ER-72 (GTN), Office of Energy
Research, U. S. Department of Energy, Washington, D.C.  20585,
(301) 903-6488. 

SUPPLEMENTARY INFORMATION:  Potential applicants are strongly
encouraged to submit a brief preapplication in accordance with 10
CFR 600.10(d)(2), which consists of two to three pages of
narrative describing the research project objectives and methods
of accomplishment.  These will be reviewed relative to the scope
and research needs of the DOE's Human Genome Program. 
Preapplications referencing Program Notice 93-12 should be
received by April 15, 1993, and sent to Dr. David A. Smith, Office
of Health and Environmental Research, ER-72 (GTN), Washington,
D.C. 20585.  Telephone and FAX numbers are required parts of the
preapplication.  A response to the preapplications discussing the
potential program relevance of a formal application generally will
be communicated within 30 days of receipt. 

It is anticipated that approximately $5,000,000 will be available
for grant awards during FY 1994, contingent upon availability of
appropriated funds.  Multiple year funding of grant awards is
expected, and is also contingent upon availability of funds. 
Previous awards have ranged from $79,000 per year up to $1,000,000
per year with terms from 1 to 3 years.  Most awards are in the
$200,000 to $400,000 per year range for 3 years.  Similar award
sizes are anticipated for new grants.  Information about
development and submission of applications, eligibility,
limitations, evaluation, selection process, and other policies and
procedures may be found in the ER Special Research Grants
Application Kit and Guide and 10 CFR Part 605.  The ER, as part of
its grant regulations, requires at 10 CFR 605.11(b) that a grantee
funded by ER and performing research involving recombinant DNA
molecules and/or organisms and viruses containing recombinant DNA
molecules shall comply with the National Institutes of Health
"Guidelines for Research Involving Recombinant DNA Molecules" (51
FR 16958, May 7, 1986), or such later revision of those guidelines
as may be published in the Federal Register.  

The dissemination of materials and research data in a timely
manner is essential for progress towards the goals of the DOE
Human Genome Program.  The OHER requires the timely sharing of
resources and data.  Applicants should, in their applications,
discuss their plans for disseminating research data and materials
which may include, where appropriate, putting cell lines, probes,
sequence data, etc., into public repositories.  Once OHER and the
applicant have agreed upon a distribution plan, it will become
part of the award conditions.  Funds to defray the costs of
disseminating materials or submitting data to repositories are
allowable; however, such requests must be adequately justified. 
Applicants should also provide timelines projecting progress
toward achieving proposed goals.

The application kit and guide is available from the U.S.
Department of Energy, Office of Health and Environmental Research,
Office of Energy Research, ER-72, Washington, D.C.  20585. 
Telephone requests may be made by calling (301) 903-6488.  The
Catalog of Federal Domestic Assistance Number for this program is

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