NATO ADVANCED STUDY INSTITUTE

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                     NATO ADVANCED STUDY INSTITUTE
                     -----------------------------

          MOLECULAR ASPECTS OF OXIDATIVE DRUG METABOLIZING
      ENZYMES AND THEIR SIGNIFICANCE IN ENVIRONMENTAL TOXICOLOGY,
                 CHEMICAL CARCINOGENESIS,AND HEALTH

                      JUNE 20 -- JULY 2 , 1993
                          KUSADASI-TURKEY


ORGANIZED BY:   Emel ARINC (TURKEY), Wolfgang KLINGER (GERMANY),
                 John B. SCHENKMAN (USA), John J. STEGEMAN(USA)



    The primary aim of Institute will be on the recent advances in
  biochemical, regulatory and molecular aspects of oxidative drug
  metabolizing enzymes. Mainly cytochrome P450 dependent and Flavin
  containing monooxygenases will be covered. Significance of these
  enzymes in genotoxicology, environmental toxicology, chemical car-
  cinogenesis will be discussed. Therapeutic P450 inhibitors and
  cytochrome P4501A1 induction in fish and its potential use in bio-
  chemical monitoring will be considered as special topics of interest.



   LECTURERS:

   Richard F. ADDISON (CANADA)       Wolfgang KLINGER (GERMANY)
   Diana ANDERSON (UK)               Sergei V. KOTELEVTSEV (RUSSIA)
   Emel ARINC (TURKEY)               David KUPFER (USA)
   Johannes DOEHMER (GERMANY)        Anthony Y.H. LU (USA)
   Yoshiaki FUJII-KURIYAMA (JAPAN)   Franz OESCH (GERMANY)
   John W. GORROD (UK)               Richard M. PHILPOT (USA)
   Helmut GREIM (GERMANY)            John B. SCHENKMAN (USA)
   Ernest HODGSON (USA)              John J. STEGEMAN (USA)
   Eric F. JOHNSON (USA)             Hugo Vanden BOSSCHE (BELGIUM)
                                     Chung S. YANG (USA)


                         SESSIONS

  Session I   : BIOCHEMISTRY AND MOLECULAR BIOLOGY OF THE MICROSOMAL
               CYTOCHROME P450 ISOZYMES
  Session II  : FLAVIN CONTAINING MONOOXYGENASES
  Session III : METABOLISM AND TOXICITY OF DRUGS AND OTHER XENOBIOTICS
  Session IV  : GENOTOXICOLOGY, PREDICTIVE TESTS, CHEMICAL
               CARCINOGENESIS AND CYTOTOXICITY
  Session V   : THERAPEUTIC AGENTS AND CYTOCHROME P450
  Session VI  : ECOTOXICOLOGICAL  ASPECTS OF CYTOCHROME P450 AND
               BIOCHEMICAL MONITORING OF AQUATIC POLLUTANTS



    Lectures, poster sessions, oral presentations and discussions
will be held from 9:00 h. to 12.30 h. and from 16.30 h. till 19:00 h.
    Approximately 75 participants will be admitted. The Institute is
located in a five-star KORUMAR Hotel which has its own beach and Con-
ference rooms in KUSADASI, on the Aegean Coast.

PARTICIPANTS
   The Advanced Study Institute will accomodate about 75 graduate stu-
dents, post-doctoral fellows and senior scientists from universities,
govermental organizations and the industry.

  Instructions  for Applications
  ------------------------------

   Persons  wishing to attend the Institute should fill out the enclosed
"Application Form" and send it to Director of ASI. Those applying for
financial assistance will be required to include a statement giving rea-
sons in support of their application and a letter of recommendation from
a senior scientist active in the field. Scientific contributions by par-
ticipants in poster sessions and in oral presentations (15 min.) are
welcome. Abstracts not exceeding one page must be in English.


  DEADLINE FOR APPLICATION and ABSTRACT SUBMISSION:

            FEBRUARY 20, 1993

  FINANCES:
     Participants are expected to cover their own travel and living
 expenses. A limited number of grants covering (part of) these expenses
 will be available for participants from NATO countries.

     NO REGISTRATION FEE IS DUE.

   Upon acceptance, a non-returnible deposit of 100 U.S. dollars will
be requested from the successful candidates. Deposits will be reimbursed
at the end of the course to the participants. The total cost including
half-board, coffe servings, abstract book, and some activities is 550
US dollars per person sharing a double room. Accomodations for the par-
ticipiants' family members are available at the same cost as for the
participiants . Children at 0-6 years of age will be free of charge.

 For application forms, write to

 Dr. Emel ARINC
 Director of ASI
 Middle East Technical University
 ODTU
            TR 06531 ANKARA-TURKEY


 Fax: (90) (4) 210 12 79
 Telex no: 42761 ODTK TR
 Tel: (90) (4) 210 10 00 ---> Ext. 3105

 For information through E-mail contact Muzaffer TAYLAN
 CONSULT1 at TRMETU.BITNET




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