DOE Human Genome Program Announcement - ELSI

Marvin.Stodolsky at Marvin.Stodolsky at
Thu Mar 3 13:44:05 EST 1994

The US Department of Energy's 1994 competition for Research
Financial  Assistance within the Human Genome Program was
announced in the Federal Register, 02/18/94 Vol. 59, No. 034,
pages 32-34, Program Notices 94-13: Human Genome - Ethical,
Legal, and Social Implications.  The full texts can also be
accessed electronically through:

   anonymous ftp TO  for  /genome/9413.txt  
   anonymous ftp TO 
                  for files /DOE/DOENOTE.TXT or /DOE/DOENOTE.EXE.
         gopher TO  
         telnet TO  

     DOENOTE.EXE is the compressed version of DOENOTE.TXT which
expands itself on DOS based systems.  DOENOTE also contains
several other DOE non-genome program notices. 

     Some background information relevant to the Genome program
is available by gopher at GOPHER.GDB.ORG


Preapplications are due by April 15, 1994 and formal applications
by July 14, 1994.  Related telephone queries should be made to
Daniel W. Drell at 301/903-4742.  Please note that the following
addresses are ONLY for the short preapplications:

US Mail                         Express Delivery Services
-----------------               -------------------------
Daniel W. Drell                 Daniel W. Drell 
  attn. Notice 94-12               attn. Notice 94-12
US Dept. of Energy              US Dept. of Energy
OHER, ER-72 GTN                 19901 Germantown Rd.
Washington, DC  20585           Germantown, MD  20874

The facsimile number is:                     (301) 903-8521.
with secretary Joann Corcoran at telephone:  (301) 903-6488.

Internet address:     Daniel.Drell at

Email submissions should use ASCII text format (please do NOT
send LaTeX, TeX or Postscript files!).

Materials for the formal applications will be returned with
responses to relevant preapplications.



Notice 94-13: Human Genome Program-
     Ethical, Legal, and Social Implications

SUMMARY:  The Office of Health and Environmental Research (OHER)
of the Office of Energy Research (ER), U.S. Department of Energy
(DOE), hereby announces its interest in receiving applications in
support of the Ethical, Legal, and Social Implications (ELSI)
subprogram of the Human Genome Program (HGP).  The HGP is a
coordinated, multidisciplinary, goal-oriented, research effort
aimed at improving technologies that will lead to a detailed
understanding of the human genome at the molecular level.  This
particular research notice encompasses research grants that
address ethical, legal, and social issues that may arise from the
use of information and knowledge resulting from the HGP.  The DOE
especially encourages the submission of applications to conduct
multidisciplinary, empirical research on privacy issues from the
creation, use, maintenance, and disclosure of genetic
information.  This may include (but is not limited to) issues of
ownership and control of genetic information and the protection
of the privacy of genetic information in various settings
including the workplace.  Applications should demonstrate
knowledge of the relevant literature, and should include detailed
plans for the gathering and analysis of factual information and
the exploration of issues associated with the ethical, legal, and
social implications of the knowledge gained from the HGP.  All
applications should include, where appropriate, detailed
discussion of human subjects protection issues; e.g., storage of,
manipulation of, and access to data.  Where survey techniques are
proposed, provisions to ensure the inclusion of women,
minorities, and potentially disabled individuals must be
described, unless specific exclusions are scientifically
necessary and justified in detail.  All proposed research
applications should address the issue of efficient dissemination
of results to the widest appropriate audience.    

The DOE is also soliciting applications for the preparation and
dissemination of educational materials in any appropriate medium
that will enhance public understanding of both the scientific
aspects and the ethical, legal, and social aspects of the HGP. 
In addition, the DOE is encouraging applications for the support
of conferences focusing on specific issues or areas of concern
related to the ethical, legal, and social implications of the
HGP.  Educational and conference applications should also
demonstrate awareness of the relevant literature, and include
detailed plans for the accomplishment of project goals,
including, where appropriate, video productions.  In the case of
educational {pg 8185} activities, the DOE strongly recommends
inclusion of assessments of effectiveness of the proposed
activities.  In the case of all conferences, a fairly detailed
and complete roster of committed speakers is necessary.  At the
completion of the conference, a summary or report is required. 
Educational and conference applications must also demonstrate
awareness of the need to reach the widest appropriate audience.  

PREAPPLICATIONS: Potential applicants are strongly encouraged to
submit a brief preapplication that consists of two to three pages
of narrative describing the research project objectives and
methods of accomplishment.  These will be reviewed relative to
the scope and research needs of the DOE's Human Genome Program. 
Preapplications referencing Program Notice 94-13 should be
received by April 15, 1994, and sent to Dr.  Daniel W.  Drell,
Office of Health and Environmental Research, ER-72 (GTN),
Washington, DC 20585.  Telephone and FAX numbers are required
parts of the preapplication, and electronic mail addresses are
desirable.  A response to the preapplications discussing the
potential program relevance of a formal application generally
will be communicated within 30 days of receipt.   

SUPPLEMENTAL INFORMATION It is anticipated that approximately
$1,000,000 will be available for grant awards in this area during
FY 1995, contingent upon availability of appropriated funds. 
Multiple year funding of grant awards is expected, and is also
contingent upon availability of funds.  Previous awards have
ranged from $60,000 per year up to $500,000 per year with terms
from one to three years.  Similar award sizes are anticipated for
new grants.  Information about development and submission of
applications, eligibility, limitations, evaluation, selection
process, and other policies and procedures may be found in the
Application Guide for the Office of Energy Research Financial
Assistance Program and 10 CFR part 605.  The Application Guide is
available from the U.S.  Department of Energy, Office of Health
and Environmental Research, Health Effects and Life Sciences
Research Division, ER-72 (GTN), Washington, DC 20585.  Telephone
requests may be made by calling (301) 903-6488.

The dissemination of materials and research data in a timely
manner is essential for progress towards the goals of the DOE
Human Genome Program.  The OHER requires the timely sharing of
resources and data.  Applicants should, in their applications,
discuss their plans for disseminating research results and
materials that may include, where appropriate, publication in the
open literature, wide-scale mailings, etc.  Once OHER and the
applicant have agreed upon a distribution plan, it will become
part of the award conditions.  Funds to defray the costs of
disseminating results and materials are allowable; however, such
requests must be sufficiently detailed and adequately justified. 
Applicants should also provide timelines projecting progress
toward achieving proposed goals.  

DATES: Formal applications submitted in response to this notice
must be received by 4:30 p.m., e.d.t., July 14, 1994, to be
accepted for merit review in September 1994, and to permit timely
consideration for award in Fiscal Year 1995.

ADDRESSES: Formal applications referencing Program Notice 94-13
should be forwarded to: U.S.  Department of Energy, Office of
Energy Research, Acquisition and Assistance Management Division,
ER-64 (GTN), Washington, DC 20585, ATTN: Program Notice 94-13. 
The following address must be used when submitting applications
by U.S.  Postal Service Express Mail or any commercial mail
delivery service, or when handcarried by the applicant: U.S. 
Department of Energy, Office of Energy Research, Acquisition and
Assistance Management Division, ER-64, 19901 Germantown Road,
Germantown, MD 20874.  

Health and Environmental Research, ER-72 (GTN), Office of Energy
Research, U.S.  Department of Energy, Washington, DC 20585, (301)

From: Federal Register, Friday, February 18, 1994, Vol.  59, No. 
034, 59 FR 8184.  "Energy Research Financial Assistance Program
Notice 94-13: Human Genome Program-Ethical, Legal, and Social

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