symposium in Melbourne, Australia

Marek T. Michalewicz marek at trout.mel.dit.CSIRO.AU
Fri Mar 18 17:53:54 EST 1994


Are you interested in knowing how the new antiviral drug to fight Influenza 
Virus was rationally designed?

Would you like to learn how the large pharmaceutical companies in the 
US, like Merck or Bristol-Myers-Squibb, utilize computational methods to 
bring new promising therapeutic compounds more quickly to the market?

Are you involved in the following research:

determination of the structure of biological macromolecules from 
x-ray or NMR experiments?

protein homology modelling and structural analysis?

analyzing sequence and structural data of proteins and nucleic acids?

constructing RFLP linkage maps of organisms by multi-point 
linkage analysis of marker data in simple crosses?

Are you a biochemist, molecular biologist, radiologist, drug designer, 
cardiologist, computational scientist or simply a person interested in 
new fascinating developments in biological and computational sciences?

:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
:::::::::::::: THEN YOU SHOULD ATTEND ::::::::::::::::::::::::::::: 
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

*******************************************************************
*******************************************************************
CSIRO SYMPOSIUM ON "COMPUTATIONAL CHALLENGES IN LIFE SCIENCES"
*******************************************************************
*******************************************************************
12-13 MAY 1994                              MELBOURNE
____________________________________________________________________
           	Aim of the Symposium: 
--------------------------------------------------------------------

Life sciences have matured to the stage when the mathematical and computer 
modelling is now possible, and often leads to new and deeper understanding 
of life processes. Computational approaches not only provide a new way 
of complementing experimental studies at the fundamental level; 
they also offer a very practical means of bringing immediate financial 
gains in the highly competetive world of medical technology, 
drug design, agrochemicals and food production.

We hope to provide a wide exposition of new trends in computational 
approaches to a selected range of important problems in medicine, physiology, 
pharmaceutical chemistry, agrochemistry, molecular biology 
and many related fields. 

Our aim is to help experimental and practising scientists 
in those fields take advantage of the power of computational methods 
and their easy availability. The hardware and software tools for such studies 
are already available in Australia. Now is the time to start using them.

--------------------------------------------------------------------
	Topics:
--------------------------------------------------------------------
The main topics are: 

1  drug design, biochemistry, molecular biology 
2  nervous system modelling and simulation 
3  traditional imaging methods and interpretation techniques: x-ray, 
	NMR, MR imaging, etc; 3D and 4D visualisation 
4  three dimensional organ modelling: heart 
5  organism modelling: virtual plants

_______________________________________
	Invited overseas speakers:
---------------------------------------

Prof Peter Kollman 
University of California, San Francisco: 
(Prof. Kollman received 1993 Computerworld Smithsonian Award 
for studies of the interaction between DNA and enzyme 
Eco RI endonuclease, with Robert Swendsen and John Rosenberg)

"The applications of molecular dynamics and free energy calculations 
to molecular interactions involving proteins, dna and ionophores"


Prof Charles S. Peskin 
Courant Institute of Mathematical Sciences, New York University 
"Three-dimensional computation of blood flow in the heart"


Prof. Julian Rosenman 
University of North Carolina, USA  
"Radiation dose therapy simulation in cancer treatment"


Dr Terry Stouch 
Bristol-Myers Squibb, USA: 
"MD simulation of drug transport through membranes"

Dr Dennis Underwood, Associate Director 
Merck Institute for Therapeutic Research
Merck & Co, USA:  
"Supercomputing for Research and Development: Drug Discovery and 
Design in the Pharmaceutical Environment"


Prof Matthew Witten,  
Head, R&D University of Texas System Centre for High Performance Computing, 
Associate Director, UT System CHPC
Department of Applications Research and Development: 

Prof Witten is the organizer and convenor of the 1st World Congress
on Computational Medicine Public Health and Biotechnology 
(24-28 April, Austin, Texas), he will give two lectures:

"Overview and summary of the 1st World Congress 
on Computational  Medicine Public Health and Biotechnology"
"Cancer - ageing cell system simulation"


Prof P. Prusinkiewicz 
University of Calgary, Canada & Division of Entomology, CSIRO:  
"Virtual plants"


Dr Robert A. Eades, Cray Research Inc., USA
Executive Director of Industry Marketing, Chemical, Pharmaceutical, 
Materials & Electronics, USA: 
"Life science applications on Cray supercomputers worldwide"

_______________________________________
        Invited local speakers:
---------------------------------------

Prof John B. Furness,
University of Melbourne, School of Medicine, 
Department of Anatomy and Cell Biology 
"Realistic models of nervous systems: 
are they achievable and will they be useful?"


Dr Ray Norton  
Biomolecular Research Institute, Melbourne
"Multidimensional NMR applications to biomolecular structure determination"


Dr Alex Sergejew, Swinburne Institute of Technology,
Center for Applied Neurosciences and Laboratory for Concurrent Computing
"Experimental and computational studies of cortex"

Prof Jim Wright, Swinburne Institute of Technology, 
Center for Applied Neurosciences
"Brain modelling"

Dr Brian Smith
Biomolecular Research Institute, Melbourne
"Enzyme mechanisms"

Dr Jose Vargese 
Biomolecular Research Institute, Melbourne  
"X-ray Macromolecular Structure Refinement by Molecular Dynamics Simulation"

Dr David Winkler 
CSIRO  Division of Chemicals and Polymers 
"Drug design"

Herbert Treutlein
Molecular Modelling Group
Ludwig Institute for Cancer Research
"Homology modelling of proteins"

_____________________________________________________
Exhibitions and demonstrations:
-----------------------------------------------------

UniChem (Dr Marek T. Michalewicz, CSIRO SSG) 
UniChem includes Molecular Quantum Chemistry programs: MNDO91, DGauss 
and CADPAC 

Biosym (Dr Anneliese Palmer, Dr Cliff Holloway)
programs include:
     Insight II, Discover, Homology, NMRchitect, Ludi, Apex, DMol, and others

MSI (Teijin/Molecular Simulations, Inc.)
programs include:
     QUANTA, CHARm, Protein Workbench, NMRgraf, Receptor, Polaris and others

Genesis (Dr David Liley, Swinburne Institute of Technology) 

Virtual Plants (Dr Przemyslaw Prusinkiewicz, CSIRO Div of Entomology) 

X-PLOR (Dr Jose Varghese, Biomolecular Research Institute) 

Mapmaker (Dr Evans Lagudah, CSIRO Division of Plant Industry)

3D&4D NMR software (Dr Ray Norton,  Biomolecular Research Institute)

"Plexus": a program for simulation of any neural circuit applied to 
propulsive activity in intestine
(Hugh Kelly,University of Melbourne, School of Medicine)

____________________________________________________________________
        Venue:
--------------------------------------------------------------------
Clunies Ross Conference Centre 191 Royal Parade, Parkville, Melbourne
_______________________________________
Attendance is open to CSIRO and other scientists,
with a target number of around 200.
_____________________________________________________
Registration fee:   
-----------------------------------------------------

before 31.3.1994 $200 (with conference dinner)   $170 (no dinner) 
after  31.3.1994 $250 (with conference dinner)   $220 (no dinner) 

Special student rates may be offered in the begining of April, 
but registrations, without payment must be first received.
*********************************************************
*Please fill in the registration slip and send promptly.*
*********************************************************
_____________________________________________________
Accommodation: Accommodation is the responsibility of participants. 
The conference center is close to the Central Melbourne District, 
Parkville and Carlton.
_____________________________________________________
Information and registration slip to be sent to: 
(e-mail registrations followed by cheque by mail accepted)

Dr Marek Michalewicz, 
CSIRO Supercomputing Support Group, 
Division of Information Technology,
723 Swanston Street, Carlton, 
Vic. 3053, Australia 
phone: (03) 282 2621;  fax: (03) 282 2600 
e-mail: marek at mel.dit.csiro.au

Please fill in and send the form below:

cut here  
*To receive discount, payment must be received before  31st March 1994
8X -------------------------------------------------------------------

Cheque payable to:  CSIRO Collector of Monies
Address: 
CSIRO Supercomputing Support Group,  
723 Swanston Street, Carlton, Vic. 3053, Austrlia;
fax to: (03) 282 2600  Attn. Dr M.T. Michalewicz 
or e-mail: marek at mel.dit.csiro.au

Name: (Prof., Dr, Mrs, Ms, Mr,.....)______________________________
Affiliation:______________________________________________________
Mailing Address:__________________________________________________
Telephone:__________________________  
Fax:________________________________
e-mail:____________________________________________
mainly interested in topics: 1   2   3   4   5  other: ______________ 
Method of payment (credit facilities not available):  
company cheque__   money order__   overseas bankdraft__ 
will attend the conference dinner: yes__   no__ 

Amount enclosed  $_______
--------------------------------------------------------------------------


ORGANIZED BY CSIRO SFUMC* AND CSIRO SUPERCOMPUTING SUPPORT GROUP

SPONSORED BY

CSIRO SUPERCOMPUTING SUPPORT GROUP
CSIRO DIVISION OF INFORMATION TECHNOLOGY
CSIRO DIVISION OF BIOMOLECULAR ENGINEERING
BIOMOLECULAR RESEARCH INSTITUTE, Melbourne
CSIRO DIVISION OF CHEMICALS AND POLYMERS
CSIRO DIVISION OF ANIMAL HEALTH
CSIRO DIVISION OF ATMOSPHERIC RESEARCH

INDUSTRIAL SPONSORS:

        CRAY RESEARCH (Australia)
        BIOSYM TECHNOLOGIES, INC.
        STORAGETEK Australia
        SILICON GRAPHICS
        GLAXO
        MOLECULAR SIMULATIONS INC.

*Commonwealth Scientific and Industrial Research Organization
Supercomputing Facility Users Management Committee
_________________________________________________________________________
Program Committee:

Dr Peter Colman,  CSIRO Division of Biomolecular Engineering
and Biomolecular Research Institute, Melbourne (Chair)
Dr Tom Spurling,  CSIRO Division of Chemicals and Polymers
Dr Mike Rickard,  CSIRO Division of Animal Health
Dr Marek Michalewicz,  CSIRO Supercomputing Support Group (Sec.)

_____________________________________________________
Organising Committee:

Dr John O'Callaghan (CSIRO Division of Information Technology - Chair)
and members of CSIRO SFUMC,
Dr Marek Michalewicz (CSIRO Supercomputing Support Group - Secretary).



	END of 2nd announcement
*************************************************************************

--
*  Dr Marek T. Michalewicz                                                    *
*  Supercomputing Support Group, Division of Information Technology, CSIRO    *
*  723 Swanston Street, Carlton, Victoria 3053, Australia                     *
*  *tel: +61 3 282 2621 *Fax: +61 3 282 2600  *e-mail: marek at mel.dit.csiro.au *



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