Jesus Joglar jjtqob at
Tue Dec 12 21:12:44 EST 1995

Food Toxins and Host Mechanisms Conditioning Toxic Responses 
June 1-4, 1996   SITGES-SPAIN 
Workshop:                                June 1-4, 1996 
Early registration:                      March 15, 1996 
Abstract submission:                     March 15, 1996 
Deadline for hotel registration:         April 10, 1996 
Workshop Secretariate:                         Workshop Venue: 
Prof. Angel Messeguer                          Hotel Antemare 
ISSX 1996 European Spring Workshop             Verge de Montserrat, 
CID-CSIC                                       08870- Sitges 
J. Girona, 18-26                               Spain 
08034-Barcelona                                Tel: 34-3-894 70 00 
Spain                                          Fax: 34-3- 894 63 01 
Tel: 34-3-400 61 21 
Fax: 34-3- 204 59 04 
E-mail: issx96 at 
The Organizing Committee cordially invites you to participate in the 
ISSX 1996 European Spring Workshop to be held at the Antemare Hotel, 
Sitges, Spain, from Saturday June 1 to Tuesday June 4, 1996. 
The objective of this event is to bring together in an informal 
workshop-setting both senior and young scientists to present and 
discuss their latest developments in the areas covered by the 
scientific program. The main subject of this Workshop is food toxins 
and host mechanisms conditioning toxic responses. This theme departs 
from more traditional ISSX topics in order to concentrate on the study 
and discussion of xenobiotics present in diet.   
The  workshop will consist of morning and afternoon plenary lecture 
sessions on Sunday and Monday. Sunday sessions will deal with general 
aspects of xenobiotic metabolism and host mechanisms conditioning 
toxic responses, while Monday sessions will be more focused on 
xenobiotics present in diet. These sessions will be complemented by 
short oral presentations. In addition, two poster sessions will be 
organized in order to give ample opportunity for attendants to present 
their contributions. Finally, a Round Table followed by a debate on 
"Diet components and health; The Mediterranean Diet: Pros and Cons" 
will be held during the Tuesday morning session.   
Sitges is a beautiful seashore Mediterranean city located 30 Km south 
of Barcelona and only 20 Km south of its international airport. Sitges 
is very well connected by highway and train from Barcelona and from 
its airport as well. This village, known as the "white city" is well 
suited for hosting visitors and is a wonderful, quiet place that will 
provide a convenient environment for fruitful scientific exchange and 
recreational activities. Weather in early June is usually sunny, mild 
and pleasant and the risk of rain is not high.  
For all these reasons the Local Organizing Committee looks forward to 
welcoming you in Sitges and will strive to make this Workshop a 
memorable scientific event and enjoyable social occasion. 
Angel Messeguer, Chairman. 
Local Organizing Committee 
Angel Messeguer (Chairman) 
Josefina Casas 
Maria Jose Gomez-Lechon 
Margarita G. Ladona 
Antonio Martinez-Tobed 
Francisco Sanchez-Baeza 
Scientific Advisory Committee 
Philippe Henri Beaune             France 
John Caldwell                     United Kingdom 
John R. Cashman                   USA 
Jose-Vicente Castell              Spain 
Ronald W. Estabrook               USA 
Corrado L. Galli                  Italy 
Frederick P. Guengerich           USA 
Peter W. Moldeus                  Sweden 
Franz Oesch                       Germany 
Takashi Sugimura                  Japan 
Nico P.E. Vermeulen               The Netherlands 
Administrative Support 
Nancy Holahan, ISSX Administrative Officer, Cabin John, MD, USA. 
Viajes El Corte Ingles, S.A. Barcelona. 
Ma. Angels Quiroga, Dpt. of Biological Organic Chemistry, CID, CSIC, 
* Abstracts 
      Deadline for submission is March 15, 1996. 
* Meeting Registration 
      Registration before March 15, 1996 
        Member                     48.000 ptas. 
        Non-member                 55.000 ptas. 
        Student                    20.000 ptas. ¤ 
        Accompanying person        18.000 ptas. 
      Registration from March 16 to May 30, 1996 
        Member                     60.000 ptas. 
        Non-member                 67.000 ptas. 
        Student                    25.000 ptas. ¤ 
        Accompanying person        23.000 ptas. 
      On-site registration beginning June 1, 1996 
        Member                     70.000 ptas. 
        Non-member                 77.000 ptas. 
        Student                    30.000 ptas. ¤ 
        Accompanying person        28.000 ptas. 
      Registration fee includes: 
        * Entrance to all sessions. 
        * Workshop program and proceedings/abstracts book. 
        * Welcome reception on Saturday. 
        * Workshop dinner on Monday. 
        * Refreshment breaks. 
        * Lunch for Sunday, Monday and Tuesday. 
        * Bus transportation from Hotel Antemare to Barcelona airport 
on Tuesday afternoon. 
      Accompanying person registration fee includes: 
        * Welcome reception on Saturday. 
        * Workshop dinner on Monday. 
        * Refreshment breaks. 
        * Lunch for Sunday, Monday and Tuesday. 
        * Bus transportation from Hotel Antemare to Barcelona airport 
on Tuesday afternoon. 
¤  A limited number of low fee registration places are available for 
student and/or post doctoral research associates. Along with your 
registration form, please send a letter from your Research Supervisor 
indicating that institutional support is not available.  
* On-site Registration 
Hotel Antemare starting at 3:00 p.m. on Saturday, June 1, 1996, and 
throughout the Workshop. 
* Cancellation Policy 
A 75% refund of registration fee will be made if written request is 
received before May 1, 1996. 
* Final Program and Abstracts Book 
The schedule for lectures and poster presentations, and the 
proceedings booklet containing the Workshop abstracts, will be 
distributed to each participant during the Workshop. 
* Poster awards 
Awards will be granted for the two best posters displayed at each 
Poster sessions. 
* Hotel Information 
All Workshop sessions will be held at the Hotel Antemare, located at 
48-50 Verge de Montserrat, Sitges. The Hotel Antemare is located 
within walking distance of Sitges beaches,  downtown, shopping center 
and restaurants. A limited block of rooms has been set aside for the 
Workshop at a special rate. To obtain this special rate, please 
complete and mail the enclosed reservation form immediately or not 
later than April 10, 1996. 
* Language 
All sessions of the Workshop will be conducted in English. 
* Special Services 
Participants with limited physical mobility or with other special 
needs, including individual dietary requirements, should contact the 
Workshop Secretariate for advice. 
* Weather 
The weather in Sitges in early June is generally sunny and mild. 
During the day the temperature is usually between 20-25 degrees 
Celsius. The sea temperature is usually at 15-17 degrees Celsius. The 
evenings can be cooler and the possibility of occasional rain does 
exist. Therefore, we suggest you bring a sweater or waterproof jacket. 
* Banking 
In Sitges there are branches of the main Spanish and selected European 
banks. Regular banking hours are generally from 8:30 a.m. to 2:00 p.m. 
Monday to Friday. Many branches have automated teller machines that 
can be accessed, usually on a 24 hour basis, by account holders.   
* Credit Cards 
Most credit cards are accepted in Spain including Visa, American 
Express and Diners Card. 
* Electrical Current 
The electrical current in Spain is 220 volts, 50 cycles. 
* Insurance 
Please ensure that you have suitable coverage for insurance policies 
from your home country in the event of illness or accident while in 
Spain. The Local Organizing Committee will accept no liability for 
personal injuries sustained by or for loss or damage to property 
belonging to Workshop participants, either during or as a result of 
the Workshop. 
* Monetary Exchange 
The monetary system in Spain is based in "pesetas" (pta.). 
International currency exchange is available at the Barcelona 
international airport, train station and at Sitges downtown banks. 
Traveler's checks in $USA are also widely accepted. 
The following guide gives exchange rates for the Spanish peseta versus 
other common world currencies as of November, 1995. 
        1 American dollar     123 ptas. 
        1 British pound       192 ptas. 
        1 French franc         25 ptas. 
        1 German mark          88 ptas. 
* Sales Tax 
Spain charges are 16% V.A.T. for most items. Rebates on non-consumable 
items may be available for non European Union residents. Please see 
Information Desk during the Workshop for more information. 
* Travel Information 
The workshop venue can be reached 
   By car 
>From Barcelona by choosing highway 16. Major highways from the rest of 
Spain and from France that reach Barcelona do connect with highway 16 
through the Barcelona circumvallation ring ("Rondas"). 
   By rail 
There are hourly connections from Barcelona Sants Central Station. The 
trip to Sitges takes 30 minutes. 
   By air 
Sitges is located 20 Km South of Barcelona International airport. Taxi 
facilities are available for transportation to Sitges (approx. cost 
6.000 pta.). In addition, a 15 minute trip by train can take you to 
Barcelona Sants Central Station, from where you can reach Sitges as 
indicated above. 
* Passport and Visa Requirements 
All participants from non European Union countries are requested to 
check on their own for passport and visa requirements. 
* Social events and Recreational Activities 
The Workshop dinner will be served at the Restaurant "La Masia", a 
traditional farm house located within walking distance from Hotel 
The Hotel Antemare offers a number of indoor and outdoor services and 
activities including swimming pool and fitness center. Swimming, 
fishing and all kinds of recreational seashore activities can be 
enjoyed in Sitges. Also, trips to Barcelona are highly recommended. 
The tasty food of the region and an overwhelming selection of wines 
and sparkling wines ("cava") will certainly find your approval.  
Saturday, June 1, 1996: 
Registration               3:00 p.m. - 7:00 p.m.   
Welcome Reception          7:00 p.m. 
Sunday, June 2, 1996: 
8:45 a.m.                  Opening remarks 
* Plenary Session 1 
Chair:                     Philippe Beaune 
9:00 a.m. - 9:40 a.m.      John Caldwell (St Mary's Hospital Medical 
School. London. United Kingdom). 
     Metabolism, in vitro genotoxicity and DNA and protein adduct 
formation in the risk assessment of carcinogenic natural allylbenzene 
food flavours. 
9:40 a.m. - 10:20 a.m.     Nico P.E. Vermeulen (Free University. 
Amsterdam. The Netherlands). 
     Structures and functions of specific GSH-S-transferases. 
10:20 a.m. - 11:00 a.m.     Brian Burchell (Ninewells Hospital and 
Medical School. Dundee. United Kingdom). 
     Xeno- and endobiotic glucuronidation in humans. 
11:00 a.m. - 11:20 a.m.    Coffee break. 
11:20 a.m. - 12:00 p.m.    John R. Cashman (Seattle Biomedical 
Research Institute. Seattle. WA. USA). 
     Human flavin-containing monooxygenase: Role in the metabolism of 
dietary constituents. 
12:00 p.m. - 12:45 p.m.    Oral Communications. 
12:45 p.m. - 2:00 p.m.     Lunch. 
2:00 p.m. - 3:00 p.m.      Poster Session 1. 
* Plenary Session 2 
Chair:                     John Caldwell 
3:00 p.m. - 3:40 p.m.      Philippe H. Beaune (CHU Necker, Inserm U75. 
Paris. France). 
     Idiosyncratic reactions to xenobiotics. 
3:40 p.m. - 4:20 p.m.      Peter J. Van Bladeren (TNO Nutrition and 
Food Research Institute. AJ Zeist. The Netherlands). 
     Influence of bioactive food components on biotransformation 
4:20 p.m. - 5:00 p.m.      Stephen Naylor (Mayo Clinic. Rochester, MN. 
     Capillary electrophoresis-mass spectrometry in the analysis of 
drug/xenobiotic metabolites and food toxins. 
5:00 p.m. - 5:20 p.m.      Coffee break. 
5:20 p.m. - 6:00 p.m.      Helmut A. Greim (GSF Inst Toxikol. 
Oberschleissheim. Germany). 
     The toxicological evaluation of potential additive effects of 
food contaminants. 
6:00 p.m. - 6:45 p.m.      Oral Communications. 
Monday, June 3, 1996: 
* Plenary Session 3 
Chair:                     Ronald Estabrook 
9:00 a.m. - 9:40 a.m.      Frederick P. Guengerich (Vanderbilt 
University. Nashville, TN. USA).  
     Interactions of aflatoxins with enzymes of xenobiotic 
9:40 a.m. - 10:20 a.m.     Alan R. Boobis (Royal Postgraduate Medical 
School. London. United Kingdom). 
     Are humans particulary at risk from dietary heterocyclic amines? 
10:20 a.m. - 11:00 a.m.    Robert J. Turesky (Nestec LTD. Research 
Center. Vers-Chez-Les-Blancs. Switzerland). 
     Safety assessment of cooked food mutagens: formation, metabolism 
and human biomonitoring. 
11:00 a.m. - 11:20 a.m.    Coffee break. 
11:20 a.m. - 12:00 p.m.    Rossanne Philen. (Toxic Oil Syndrome 
Program. CDC, Atlanta, GA. USA) . 
     Toxic Oil Syndrome: unique challenges and Toxicology. 
12:00 p.m. - 12:45 p.m.    Oral Communications. 
12:45 p.m. - 2:00 p.m.     Lunch. 
2:00 p.m. -  3:00 p.m.     Poster Session 2. 
* Plenary Session 4 
Chair:                     Nico P.E. Vermeulen 
3:00 p.m. - 3:40 p.m.      Leif Kronberg (Abo Akademi University. 
Abo/Turku. Finland). 
     Chlorohydroxyfuranones. Mutagenic compounds found in chlorine 
disinfected drinking water. 
3:40 p.m. - 4:20 p.m.      Jean-Claude Ruf (Office International de la 
Vigne et du Vin. Paris. France). 
     Wine: is it a healthy drink? 
4:20 p.m. - 4:40 p.m.      Coffee break. 
4:40 p.m. - 4:20 p.m.      Marcel Robertfroid (Univ. of Louvaine. 
Brussels. Belgium). 
     Protection against toxic effects of xenobiotics, a functional 
effect of food constituents. 
5:20 p.m. - 6:05 p.m.      Oral Communications. 
8:30 p.m.                  WORKSHOP DINNER 
Tuesday, June 4, 1996: 
9:00 a.m.                  ROUND TABLE: Diet Components and Health. 
The Mediterranean Diet: Pros and Cons. 
Jose-Vicente Castell, Chairman (Centro de Invest. Hosp. Univ. "La Fe". 
Valencia. Spain). 
9:00 a.m. - 9:20 a.m.      Abel Marine (University of Barcelona. 
Barcelona. Spain). 
     Mediterranean diet: foods and facts. 
9:20 a.m. - 9:40 a.m.      Corrado L. Galli (Ist. Scienze 
Farmacologiche. Milano. Italy). 
     Risk and benefit of natural and synthetic elements present in 
9:40 a.m.- 10:00 a.m.      Ronald W. Estabrook (Univ. Texas 
Southwestern Medical Center. Dallas, TX. USA). 
     Contribution of diet to cancer - Chemicals or calories? 
10:00 a.m. - 10:20 a.m.    Robert Kroes (National Institute of Public 
Health-Environmental Hygiene. Bilthoven. The Netherlands). 
     Natural substances: a gift from heaven or a thread to man. 
10:20 a.m. - 10:40 a.m.    Carlos Gonzalez (Institut de Recerca 
Epidemiologica i Clinica. Mataro. Spain). 
     Epidemiological evidence on protective factors in the 
Mediterranean diet. 
10:40 a.m. - 11:15 a.m.    Coffee break. 
11:15 a.m. - 1:00 p.m.     Debate 
1:00 p.m. - 1:15 p.m.      Closing remarks 
1:15 p.m.- 2:30 p.m.       Lunch 
The ISSX Abstract book will include all presentations listed in the 
Workshop program. 
      * Who is eligible to submit an abstract 
Authors who present posters need to be registered at the Workshop and 
only one poster per registration will be considered for this Workshop. 
      * Abstract deadline 
The deadline for the receipt of abstracts in the Organizers 
Secretariate is March 15, 1996. 
      * Abstract format 
Only abstracts which confirm to the prescribed format outlined below 
will be accepted. Abstracts will be reproduced as submitted. Please 
refer to the sample of abstract enclosed with this Preliminary 
1. The preferred size and typeface are 10-point helvetica (1st choice) 
or 10-point-geneva. If not available, please use similar typeface. 
Please print or type directly on the original abstract form, making 
every effort to produce the best possible dark black image. Do not 
type on the blue lines. 
2. Abstracts should be printed single space. If possible, please 
right-justify margins. Utilize all space within the blue box to 
clearly describe the objectives, methods used, results and conclusions 
of studies reported. Space not used will be "wasted" because each 
abstract will occupy one full page. 
3. Title of paper should be typed in ALL CAPS. 
4. Please begin a new line for authors' names and a new line for 
authors' addresses. Include first name, middle initial, last name, and 
complete address (including postal code or other mail code and 
country) for all authors. 
5. Please underline name of presenting author. 
6. Place a number (in superscript) after the name of each author. This 
number should correspond to author's address. Authors who share the 
same address should be assigned to the same number. 
7. Please leave a space between the heading and abstract proper. 
8. The use of trivial and company code names to describe chemicals is 
discouraged. In all cases chemicals should be clearly defined using 
accepted IUPAC nomenclature. The use of structures to describe complex 
compounds (especially if chemical nomenclature is complex) is 
encouraged. If illustrations or drawings are included, they must 
appear within the blue box. 
9. Use figures and/or tables rather than only text when preparing the 
abstract if this provides a more easily understood abstract. Please 
keep in mind that your abstract will be printed exactly as you submit 
it, at full size. Be sure that figures and tables are easily legible. 
Please avoid the use of scotch tape. Use of typewriter correction 
fluids is permitted. 
      * Direction for submitting abstracts. 
Please mail, unfolded, an original plus three copies of each abstract, 
as well as the Notification on Poster Abstract Receipt/Poster Session 
Information Card, before March 15, 1996, to the address below. Do not 
send abstracts by Fax. Please be sure to clearly print your address on 
the Notification on Poster Abstract Receipt/Poster Session Information 
Prof. Angel Messeguer 
ISSX 1996 European Spring Workshop 
J. Girona, 18-26 
      * Notification of abstract acceptance 
The Organizing Committee will review abstracts for confirmation to 
format guide and scientific merit, and notify of acceptance. 
Notification cards will be returned to authors and will include poster 
number and poster session. 
* A notification will be also forwarded to authors of abstracts 
selected for presentation as short oral communications. 
1. Make all material readable from 1.5 meters distance. 
2. The top section of the poster should contain the title, authors and 
affiliations. Letters should be at least 2.4 cm high. 
3. A separate section containing the abstract, as published in the 
Proceedings, should be placed in the upper left. 
4. State objectives clearly and give clear experimental details. 
5. State conclusions briefly and clearly. 
6. Judicious use of color can often add emphasis. 
1. The poster board surface is 220 cm. high and 95 cm. wide. 
2. Posters are normally presented by the author whose name is 
underlined on the abstract. 
3. Posters are to be mounted, on the assigned board, starting at 8 
p.m. on the assigned day (Sat., Sun.). Boards will be numbered to 
correspond to the asbtract number. 
4. Adhesives to fix posters will be provided. 
5. Presenters are to be present from 2 p.m. to 3 p.m. (Sun., Mon.). 
6. Posters are to be removed by 7 p.m.. 
The organizers gratefully acknowledge financial support of this 
Workshop which has been granted at this line from 
Laboratorios Almirall 
Apple Computer Espa#a 
Comision Interministerial de Ciencia y Tecnologia 
Agriculture and Fisheries Programme of the European Union 
Direccion General de Investigacion Cientifica y Tecnica 
Generalitat de Catalunya 
Caixa de Pensions "La Caixa" 
The FISS-TOS Program 
TNO Nutrition and Food Research Institute 
Acknowledgment of all support received will be made in the final 
program, the ISSX Newsletter and the Proceedings/Abstracts Book.

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