Announcement of Special Year Workshop, DIMACS, Rutgers University

[Barbara Quigley]

March 24, 1995:  MiniWorkshop on Molecular Biology
		 Sequence-Based Methods for Protein Folding 
		 DIMACS, Busch Campus, Rutgers University
		 Piscataway, New Jersey
		 Org: Bonnie Berger

In the last several years, the focus on protein structure and folding has
begun to shift from physical modeling to pattern matching.  What has happened
is that, against initial expectation, the structure of enough proteins has been
learned that there are definite patterns that are observable and that have
great predictive value both for structure and function. For instance,
recently, some researchers have started exploring some subtasks in protein
structure prediction from a discrete algorithmic point of view.  Investigators
have had some initial success on some problems of protein geometry, e.g., three
dimensional surface matching, and in predicting, or detecting structure from
sequence data, e.g., motif recognition from sequence data. Thus, the study of
protein structure is becoming much more the study of sequence and critical
conserved features from sequence, and that makes this topic very much a topic
where discrete mathematicians can make contributions. These ideas are far from
mature and their long-term relevance is unclear.


	List of Talks


Jonathan A. King, MIT 
	`The relationship between protein sequence and structure: 
        what are the questions'

Bonnie Berger, MIT
        `Algorithms for protein structural motif recognition'

Sorin Istrail, Sandia National Labs
        `Protein folding in the hydrophilic-hydrophobic model:
        achieving speed and close to optimal stability through plausible
	folding pathways'

David Haussler, UC Santa Cruz
	`Hidden Markov models for proteins'

Jeanette Schmidt, Polytechnic University 
	`Can algorithms predict common epitopes in coiled-coil proteins'

Chip Lawrence, Wadsworth Labs and NIH
	`Bayesian models for multiple local sequence alignment and 
        structural prediction by homology'

********************************************************
Please mail or email the following registration form to 
toci at dimacs.rutgers.edu


                    DIMACS Workshop Registration Form
                Sequence-Based Methods for Protein Folding
                              March 24, 1995

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