ERICE 2nd Advanced School on Biological NMR

Jean Francois Lefevre lefevre at
Mon Jan 23 18:07:00 EST 1995

2nd Advanced School on Biological Magnetic Resonance : "Dynamics and
the Problem of Recognition in Biological Macromolecules"

Place : Erice, Sicily
Arrival : Friday, may 19
Departure : Tuesday, may 30

Purpose :
	The School will be devoted to the analysis by Nuclear Magnetic
Resonance of the dynamic behaviour of biological macromolecules and
its implication in the mechanism of recognition between macromolecules
or macromolecules and small substrates. Approaches to the problem by
Molecular Simulation and X-ray Crystallography are also included in
the programme.

Format :
 The programme is constructed on morning lectures and afternoon
workshops and tutorials. Oral communications related to the topic of
the day and selected by the lecturers will be presented by the
students during workshops. The lecturers will answer questions,
preferably written in advance by the students, during tutorials.

Programme :

Basic NMR Methods for Structure and Dynamic Studies : Basics of liquid
state NMR spectroscopy : Hartmut Oschkinat (EMBL, Heidelberg, Germany)
- Basics of solid state NMR spectroscopy : Stanley Opella (University
of Pennsylvania, Philadelphia, USA) - Heteronuclear relaxation and
molecular dynamics : Gerhard Wagner (Harvard, Boston, USA) - Proton
exchange and internal dynamics : Walter Englander (University of
Pennsylvania, Philadelphia, USA) - Methods for isotopic labelling of
biomolecules : John Markley (University of Wisconsin, Madison, USA)

Simulated and Observed Molecular Dynamics : Molecular dynamics and
interaction simulation : Martin Karplus (Harvard, Boston, USA) -
Simulating protein and nucleic acid molecular dynamics : Michael
Levitt (Stanford University, USA) - Dynamics observed in the trp
repressor : Oleg Jardetzky (Stanford University, USA) - Dynamics of
peptide observed by NMR and other physical methods : Rudolf Rigler
(Karolinska Institute, Stockholm, Sweden)

Proteins-Small Molecules Interactions : Enzyme-ligand and inhibitor
interaction : Gordon Roberts (University of Leicester, England) -
Structural and dynamical consequences of ion binding on
metalloproteins : Sture Forsen (University of Lund, Sweden) - Dynamics
of Polysaccharides : R.G. Schulman (Yale University, USA)

Protein Motion and Folding : Protein structure and dynamics studied by
spectral editing : John Markley (University of Wisconsin, Madison,
USA) - Pathways of protein folding : Christopher Dobson (University of
Oxford, England)

Nucleic Acids and Protein-Nucleic Acid Interactions : Plasticity of
DNA structure and mutagenesis : Jean-Franois Lefevre (Louis Pasteur
University, Strasbourg, France) - Structure and dynamics of RNA :
Cornelius Hilbers (NSR Center, Nijmegen, The Netherlands) -
Interaction between trp repressor and trp operator : Oleg Jardetzky
(Stanford University, USA) - NMR studies of protein-Nucleic acid
complexes : Rolf Boelens (Utrecht University, The Netherlands)

Protein-Protein Recognition : Protein A and G interactions with
antibodies : Gordon Roberts (University of Leicester, England) -
Antigen and superantigen recognition by MHC class II receptor : Ted
Jardetzky (Harvard University, Cambridge, USA) - Inhibitor-protease
interactions : Tad Holak (Max-Planck-Institut, Mnchen, Germany) -
Crystallographic studies of protein-protein interactions : Rudolf
Ladenstein (Karolinska Institute, Stockholm, Sweden)

Protein-Lipid Interaction : NMR studies of protein membrane
interaction : Stanley Opella (University of Pennsylvania,
Philadelphia, USA)

General information : 

The total fee, including full board and lodging (arranged by the
school) and registration, amounts to 1000$.

Fellowships will be available covering partially or totally the fees.
Travel grants will also be given. The decision will be made right
after the closing date.  All applicants are elligible. The fellowships
will be given according to the status of the applicants.

Prospective  participants should apply to either : 

Pr Oleg Jardetzky, Stanford Magnetic Resonance Laboratory, Stanford
University, Stanford, CA 94305-5055, USA - tel: (1) 415 723 6270 - fax
: (1) 415 723 2253 - jardetzky at

or : 

Pr Jean-Franois Lefvre, ESBS, CNRS-UPR9003, Universite Louis Pasteur,
Bld Sbastien Brant, F67400 Strasbourg-Illkirch, France - tel: (33) 88
65 52 69 - fax : (33)88 65 53 43 - lefevre at

Application should state : 1) date and place of birth, nationality,
qualification and present position; 2) address, fax and phone numbers
and email address; 3) list of publications or summary of research.

Abstract may be submitted for consideration for oral or poster presentation.

Closing date for receipt of applications is March 20, 1995
Jean-Francois LEFEVRE
15, rue Descartes
67084 Strasbourg Cedex
e_mail. lefevre at

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