RECOMBINATION/bionet.molbio.recombination PASSES: 165 YES to 1 NO

BIOSCI Administrator biosci-help at
Wed Oct 11 23:37:27 EST 1995

I am pleased to announce that the proposal to create the
mailing list/newsgroup RECOMBINATION/bionet.molbio.recombination
passed by 165 YES votes to 1 NO vote.

We will proceed to create this group as soon as possible.  E-mail
users, please do not request subscriptions until you see a note posted
in BIONEWS/bionet.announce that the group is ready for use.


				Dave Kristofferson
				BIOSCI/bionet Manager

				biosci-help at

Proposal to establish RECOMBINATION/bionet.molbio.recombination

Proposed USENET name:           bionet.molbio.recombination  (unmoderated)

Proposed mailing list name:     RECOMBINATION

Proposed e-mail addresses:      recom at
                                recom at

Discussion leaders:

*Note: Area of expertise is written in brackets

Graham Dellaire,  e-mail: popa0206 at (b2xe at
Department of Medicine (Div. of Exp. Medicine)
McGill Univeristy,
Montreal, Quebec, Canada 
*(Genome Accessibility, Line-1 sequences, Gene Conversion and Ectopic Int.)

George Szatmari,  e-mail: szat at
Assistant Professor
Departement de Microbiologie et Immunologie
Universite de Montreal
CP 6128 Succursale Centre-Ville
Montreal, Quebec H3C 3J7
phone (514)343 5767  fax (514)343 5701
*(Site Specific Recombination Sytems)

Terry Chow e-mail: MDTY at
Associate Professor
Department of Oncology
Division of Radiation-Oncology
McGill University
Montreal General Hospital
1650 Ave. Cedar
Montreal, Quebec H3G 1A4
phone (514)934 8040 ext. 4179
fax (514)934 8220
*(Mammalian Genetics/gene therapy)

Dana Lasko e-mail: CZDL at
Assistant Professor of Medicine and Human Genetics
Project Director
Terry Fox Molecular Oncology Group
Lady Davis Institute for Medical Research
3755 Cote-Ste-Catherine Rd.
Montreal, PQ
Phone 340-8260 ext. 3454 (office and machine) or  ext. 5251 (lab)
Fax 340-7502
*(Replication and Recombination)


The purpose of the RECOMBINATION newsgroup is to provide a proper
forum for the discussion of issues pertaining and involving recombination 
of DNA or RNA, in its many forms (see _Topics of Discussion_).  Primarily 
it should enable those researchers who work in recombination or aligned 
fields to communicate ideas and information, as well as, provide a chance 
collaboration among national and international research groups.

Topics of Discussion include:
1. Gene conversion and ectopic integration 
2. Genome accessibility and nuclear/chromosome structure and recombination
                    -Matrix attachment sites (MARS)
                    -nucleosomes, histone 1 
                    -recombination hotspots
                    -fragile sites 
                    -origins of replication
3. Effect of DNA topology on recombination (Triple strand, Z-DNA, cruciform, 
bent etc)
4. Homologous recombination vs. nonhomologous or illegitimate 
                    -comparisons between bacterial, yeast and higher 
eukaryotic recombination
                     systems (ex. fungi, mammals) 
5. Models of recombination (One-end invasion, Double strand Break Repair, 
SSA etc)
6. Site-specific recombination systems (invertase, Cre and Flp recombinase 
7. Specific recombination systems in complex organisms
                    -VDJ recombination
                    -Antigenic variation and recombination (ex. 
trypanosomes, HIV, N.gonorrhea) 
                    -Yeast mating type locus 
8. Transcription and recombination 
9. DNA replication and recombination (ex. gene amplification (DHFR etc))
10. Evolution of the Genome
                    -retroposons (Line-1, Sine's), retroviruses and 
                    -formation of gene clusters and comparative mapping
                    -recombination between other repeat elements (alpha 
satellites, telomeres)
11. DNA repair systems and recombination (DSB and mismatch repair)
                    -including DNA repair deficient diseases (ex. Xoderma 
12. Applications of recombination
                    -Gene therapy
                    -Transgenics and gene transfer
13. Viral diversity through RNA recombination
14. Population genetics and recombination:i.e. as a source of allelic 
and as a measure of genetic exchange within and between populations.

In addition this newsgroup provides:

        A forum for the exchange of information about future congresses
        and meetings in areas of molecular biology relating to recombination

        A forum for the exchange of information about textbooks, internet
        resources, visual materials, and computer programs.

        A source of quick help for last-minute troubleshooting, sources of 
        and practical advice; in areas such as
                     -Vector design for transgene experiments
                     -Gene transfer techniques
                     -Animal models and cell lines
                     -Gene therapy protocols 

Subscribers are welcome.  Contributions within the functions outlined
above are encouraged.

The newsgroup is -UNMODERATED-.

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