Remote Processing Tools available

[EMBnet]

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HASSLE has been completely redesigned to feature a  structured  application
programmer's interface (API). This set of tools is based on  HASSLE v5  and
integrates with the GCG (Genetics Computer Group) interface. The collection
of  tools  covers  sequence  searching  and gene analysis. Major authors of 
HASSLE v5 tools are F.Eggenberger, R.Doelz, N.Redaschi and M.Schmitz.

This release of HASSLE tools does not yet  include the SRS interface but an
announcement will separately be issued later. 

Note that a  previous  announcement of services run via HASSLE covered  the 
FastAlert service which is available via anonymous ftp  as described  below 
(look in the 'fastalert' directory).The service has been very well accepted 
by the community.

The source code needed for this release of HASSLE tools is available at the 
ftp archives:

       ftp://ftp.switch.ch/mirror/embnet-ch/bioftp-sw/hassletools.tar.Z
       ftp://ftp.switch.ch/mirror/embnet-ch/bioftp-sw/HASSLETOOLS.BCK
       ftp://bioftp.unibas.ch/bioftp-sw/hassletools.tar.Z
       ftp://bioftp.unibas.ch/bioftp-sw/HASSLETOOLS.BCK


Access to the following tools is provided: 


EXPLORA
=======

EXPLORA predicts various features of yeast DNA sequences. It was written by 
Angelos KALOGEROPOULOS, Centre Universitaire d'Orsay, France.  Servers  are 
running on VAX/VMS and on Solaris operating systems.


GENEFINDER
==========

GENEFINDER programs predict various features of DNA sequences with statistical
methods. Main autor of the programs is V.Solovyev, Department of Cell Biology,
Baylor College of Medicine. Servers are running on Digital Unix and on Solaris 
operating systems.


MPSRCH
======

MPsrch performs Smith and Waterman searching for  similarity between a query
sequence and a preformatted sequence database. MPsrch is primarily  used for 
rapid protein database searching, but also available to do DNA searches. The
service is running  on the powerful 4096-processor MasPar Computer  of Basel 
University using MPsrch (C) University of Edinburgh, distributed by Intelli-
Genetics Inc. 




Integration of these client tools into your environment
*******************************************************

The  services are integrated in the GCG package and use the API (program lib-
rary) of the GCG package. A valid GCG license is required to compile this re-
lease of HASSLE tools. GCG is copyright by Genetics Computer Group, Inc., 575 
Science Drive,  Madison,  Wisconsin, USA  53711. The WPI mode of this package
is  supported. Note that this release of HASSLE tools  does  NOT  contain any 
computational programs itself but the client programs exclusively.


Cost of the services 
********************

The services are offered on an experimental basis  and are available for  free
up to the limits  defined by licenses and  availability of resources at Basel.
These limits are generously defined  and allow individuals to use the services 
(institutions are kindly asked to inquire).  Services are available  unlimited
in Switzerland upon registration,provided that EMBnet Switzerland will receive
continuous funding as scheduled.


Acknowledgements
****************

We  would like to thank all who support this facility, including the Schweize-
rische  Nationalfonds,  the  Bundesamt  fuer Bildung und Wissenschaften, Basel 
University, the Universitaetsrechenzentrum  Basel, hard- and software vendors,
sponsors of EMBnet Switzerland, and numerous colleagues in academia.