Symposium: Therapeutic Antibody Tech 95

PAIMM paimm at
Sat Sep 30 01:21:09 EST 1995

Therapeutic Antibody Technology 95 Oct. 30-Nov. 1, San Francisco
Andreas Plückthun, Zurich, "Multivalent and Bispecific Antibody Fragments,
Optimized by Protein Engineering" Ira Pastan, NIH, "The Development of
Recombinant Immunotoxins for the Treatment of Cancer" Karl-Erik Hellstrom,
Bristol Myers, "Immunoconjugates and Immunotoxins for Therapy of Human
Carcinoma-A Progress Report" Paul Carter, Genentech, "Knobs Into Holes:
Engineering of Antibody CH3 Domains for Heavy Chain Heterodimerization"
John Reno, NeoRX, "Radiotherapy of Solid Tumors with Antibody
Pretargeting" Kevin Johnson, CAT, "Human Antibody Libraries" Andrew
Griffiths, Cambridge, UK, "Phage Display Fab lox Libraries" Dennis Burton,
Scripps, "Library Antibodies as Anti-Virals" Carl Borrebaeck, Sweden,
"Homogeneous Selection of Phage derived from in vitro Immunized Human
B-Cells" Gary Barsomian, Genzyme "Selection of High Performance Antibodies
to Novel Cell Surface Markers from Phage Display Libraries" Carlos Barbas,
Scripps, "Selecting and Evolving Antibody Function" Aya Jakobvits, Cell
Genesys, "Human Antibodies Produced by Mice Engineered  with Human Ig
YAC's"Panel Discussion: Advantages and limitations of novel approaches for
generation of  human antibodies: Library techniques (Immune vs. naive vs.
semi-synthetic; scFv vs. Fab vs. YAC mice, in vitro immunization) Ian
Tomlinson, Cambridge, UK, "Diversity of human V region repertoire" Tom
Scanlan, UCSF, "Structure and Function of a Catalytic Antibody" Ian
Wilson, Scripps, "Detailed Structure Studies of the Antibody Molecule"
Peter Schultz, UC Berkeley, "Chemical Aspects of Antibodies" Peter Hudson,
CSIRO, Australia,
"Design, 3D-Structure and Affinity Maturation of Bifunctional Antibodies"
Bob Irving, CSIRO, "Phage Display, Library Selection and Mutation for the
Engineering of Antibody Affinity and Specificity" James D. Marks, UCSF,
"Molecular Evolution of Antibody Affinity Using Phage Display" Willem
Stemmer, Affymax, "Enzyme and Antibody Evolution of by DNA Shuffling"
Hennie Hoogenboom, Netherlands, "High Affinity Human Antibodies by Phage
Display"Peter Pack, Morphosys,  "Optimization Technologies For rapidly
Engineering Multivalent Antibody Fragments" Interactive Workshop: Making
Phage Display Work For You
Phage display has become a powerful tool for isolating novel antibody
specificities and manipulating antibody affinity.  Successful results,
however, have been limited to relatively few laboratories worldwide, and
the technology has been described by some as "non-robust."  This workshop
will: 1) examine the potential uses and limitations of phage antibody
libraries;  and  2) Identify common
difficulties encountered when constructing and manipulating phage antibody
Andrew Hiatt, Planet Biotech, "Production of Secreting IgA Antibodies in
Plants"Sherie Morrison, UCLA, "Genetically Engineered Antibodies With
Improved Functional Properties"Inder Verma, Salk Institute, "scFv
Targeting of Retroviruses for Gene Therapy" Glen Lilley, CSIRO, "Rapid
of HIV1 and HIV2 Using Recombinant Fab and extended scFvs with
Proteolytically Stabilized Epitopes" Wayne Marasco, Harvard, "Advances in
Intrabodies for Gene Theray of HIV-1-Infection"Jim Huston, Creative
BioMolecules "Perfecting Single-Chain Fv Imaging Agents" Louis Weiner, Fox
Chase, "Tumor-Targeting Properties of Anti-C-erbB-2 sfv" Antonio
Grillo-Lopez, IDEC, "Effective Immunotherapy of Relapsed B-Cell Lymphoma
with an Anti-CD20 Antibody (IDEC-C2B8)" Lars Ostberg, Protein Design,
"Human and Humanized Monoclonal Antibodies; Technology and Clinical
Application" Martin Rosenberg, SKB, "Reshaped Human Antibodies for the
treatment of RSV infections" Paula M. Jardieu, Genentech, "Novel
Therapeutic Antibodies: Anti-IgE, and anti-CD11A"
Kerry Chester, Royal Free Hospital, London, "Studies of a phage-derived
anti-CEA scFV" Stephen Squinto, Alexion, "Anti-Inflammatory Efficacy of
Complement-Specific Recombinant Antibodies"Anthony Conley, Merck,
"Therapeutic antibody fragments" Nigel Low
Sponsor: Palo Alto Instit. Molecular Medicine 2462 Wyandotte St., Mt.
CA 94043. T: (415) 694-4996; F: (415) 694-7717; e-mail: PAIMM at AOL.COM. 

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