ICAAC satellite pharmacokinetic conference, September 13-14, 1996
Roger Jelliffe
jelliffe at hsc.usc.edu
Thu Jun 6 17:26:56 EST 1996
June 10, 1996
Dear Colleague:
The Laboratory of Applied Pharmacokinetics of the USC School of
Medicine is putting on another satellite pharmacokinetic conference
on September 13th and 14th, 1996, just before the annual ICAAC
meeting from September 15-18, in New Orleans, Louisiana. It is on
"Model-Based, Goal-Oriented Drug Therapy: New Advances in Population
PK/PD Modeling, Individualized Antibiotic Regimens, and 'Multiple
Model' Drug Dosage". The emphasis will be on general aspects of and
new advances in Population Modeling, modeling drug diffusion, and
efficacy in kill. CME credit is being sought.
WHERE? WHEN? The conference will be held on Friday and Saturday,
September 13 -14, 1996, in a room in the Marriott Hotel in New Orleans.
One must arrange travel, hotel, and meal accommodations independently.
Specific room information will be mailed to registrants as the room is
assigned to us.
The conference is intended to increase the understanding of
recent new advances in Population Pharmacokinetic Modeling and its role
in optimization of clinical trials and optimal antibiotic therapy. The
concepts and software to implement them (the parametric USC*PACK clinical
and iterative Bayesian and the nonparametric NPEM2 programs) are intended
for general use, with special application to the optimal modeling of
drugs used in cardiovascular and infectious disease, AIDS, cancer,
transplant situations, psychiatric illnesses, and for Phase 1-2 and
2-3 trials and concentration-controlled clinical trials. Information
obtained in this conference can also be implemented on other software.
WHO IS IT FOR? The conference is for physicians and pharmacists with a
working knowledge of pharmacokinetics (Vd, Kel, etc) to apply modern
parametric and nonparametric modeling concepts to the study of population
models. Methods to describe diffusion of antibiotics into simulated
endocardial vegetations, the post-antibiotic effect, and its results on
bacterial killing curves will be discussed, and 'Multiple Model' (MM)
approaches to optimally precise dosage regimens will be introduced.
Applications to Trimethoprim, Aminoglycosides, Vancomycin, Digoxin, and
other drugs will also be discussed.
BRING YOUR NOTEBOOK! For those who already have or wish to obtain
relevant clinical software for the purposes of this workshop, and who
wish to bring it in your own laptop or notebook computer to the workshop,
you are cordially invited to bring it along to obtain further tutorial
and hands-on experience.
OBJECTIVES: After the conference, participants should be able to: 1) Define
the concepts behind parametric and nonparametric population modeling,
2) Understand the iterative Bayesian and nonparametric NPEM2 population
modeling programs, 3) Implement population modeling and Bayesian adaptive
control methods to introduce a new drug to the marketplace with optimal
strategies for its precise and safe use, 4) Compute bacterial growth and
killing curves and drug diffusion into endocardial vegetations, and
5) Understand the application of Bayesian Adaptive Control concepts to
practical aspects of managing drug therapy optimally for patients.
THE FACULTY are: Roger Jelliffe, M.D., Prof. of Medicine, USC School of
Medicine, Los Angeles, CA, Course Coordinator; George Drusano, M.D., Chief
of Clinical Pharmacology, Albany Medical College, NY, Courtney Fletcher,
Pharm.D., University of Minnesota School of Pharmacy, Alan Forrest,
Pharm.D., Director of Pharmacometrics and Biostatistics, Millard Fillmore
Hospital, Buffalo, NY, George Jaresko, Pharm.D., USC School of Pharmacy,
Pascal Maire, Pharm.D., Hospital Antoine Charial, Hospices Civils de Lyon,
France, and John Rodman, Pharm.D., Vice Chairman, Pharmaceutical Department,
St. Jude Children's Research Hospital, Memphis, TN.
Please call (213) 342-1300, or Fax us at (213) 342-1302 if you have
any questions.
Sincerely,
Roger W. Jelliffe, M.D.
Professor of Medicine
Preliminary Program: "Model-Based, Goal-Oriented Drug Therapy: New
Advances in Population PK/PD Modeling, Individualized Antibiotic Regimens,
and 'Multiple Model' Drug Dosage".
*************************************************************
Day 1 - Friday, September 13, 1996
*************************************************************
8:30 AM - Registration
9:00 AM - Welcome - Dr. Roger Jelliffe
9:05 AM - An Overview of Population Modeling - Dr. Jelliffe
9:15 AM - Parametric Population Models - Dr. Alan Forrest, SUNY, Buffalo
Naive Pooling, Standard Two Stage, NONMEM
9:45 AM - The Parametric Iterative 2-Stage Bayesian (IT2B) Procedure
- Dr. Forrest
10:15 AM - Nonparametric Population Models - Dr. Jelliffe
NP Maximum Likelihood
NP Expectation - Maximization
Their Relationship to the Separation Principle and to Optimal
Drug Regimens
10:45 AM - Break
11:00 AM - Clinical and Research Issues in Population Modeling
- Dr. Jelliffe
Evaluating Renal Function
Determining the Assay Error Pattern and the Weighting Scheme
for Measurements
When to Get Serum Levels: Optimal Sampling Schedules
Modeling Environmental Errors in Dosage Preparation and
Administration
11:45 AM - Modeling Pharmacologic Effects and Drug Binding to Effect Sites
- Dr. Jelliffe
12:00 Noon - Current Bayesian Modeling and Clinical Models of Drug
Diffusion - Dr. Jelliffe
12:15 PM - Modeling Bacterial Growth and Kill, and the Post-Antibiotic
effect - Dr. Jelliffe
12:30 PM - Lunch
1:30 PM - Modeling Antibiotic Combinations and Killing - Dr. Forrest
2:00 PM - "Multiple Model" Adaptive Control and Optimal Drug Dosing
- Dr. Jelliffe
2:30 PM - Applying "Multiple Model" Concepts to Therapy with Suramin
- Dr. Forrest
3:00 PM - Break
3:15 PM - How to make a Population Model of Amikacin with NPEM2 - Dr. Jelliffe
3:35 PM - The Front part - an Iterative Bayesian Population Modeler
- Drs. Jelliffe and Forrest
Selecting patient data file types
Evaluating Bioavailability
Parameterizing the Model: Choosing Volume, 1/V, Clearance,
or Kel
Entering the Assay Error Pattern Polynomial
Selecting the Convergence Criterion and iterations
Defining the first Bayesian prior
Setting the Initial estimates for the parameter ranges
Defining the ranges to pass to the nonparametric back part
4:15 PM - The Back part - the Nonparametric Population Modeler itself
- Drs. Jelliffe and Forrest
Using the program the standard way - picking up data and ranges
from the front part
Selecting the number of grid (support) points for the initial
joint probability density
function (PDF)
Choosing plot and print options
Evaluating the Nonparametric Output
The log-likelihood function
The difference between a cycle likelihood and the max
The means, modes, skewnesses, kurtoses, and
the percentiles
New Descriptors of Dispersion - the DF-50 and DF-95
The 2-D plots of the Marginal PDF's
The 3-D plots of pairs of Joint Marginal PDF's
Comparing these with covariances and correlations
Summarizing the grid points and their probabilities
Linking Nonparametric models to Multiple Model Adaptive
Control
Evaluating the convergence - Absolute and normalized
convergence plots
Evaluatine the entropy and the scaled information of
a distribution
Getting individual patient parameters as a
"population of one"
5:30 PM - Adjourn
*************************************************************
Day 2 - Saturday, September 14, 1996
*************************************************************
9:00 AM - A Review of Yesterday's Population Modeling - Dr. Jelliffe
9:15 AM - A tougher Problem: Modeling Trimethoprim - Drs. Jelliffe,
Forrest, and Jaresko
10:15 AM - Running the modeler without the front part - Dr. Jelliffe
Recovering and continuing after a power failure, or continuing
a previous run
Plotting results of a previous run
10:30 AM - Break
10:45 AM - Clinical Applications: Digoxin - Dr. Jelliffe
Planning the initial regimen. Controlling the Peripheral
Compartment
An interesting patient with Atrial Fibrillation
A patient with very high levels - why?
11:15 AM - Clinical Applications: Trimethoprim - Dr. Jelliffe
Setting the goals for PCP pneumonia
11:45 AM - Clinical Applications: Antiviral Pharmacodynamics
- Dr George Drusano
12:30 PM - Lunch
1:30 PM - Clinical Applications: Individualizing Cancer Chemotherapy in
the Pediatric Patient -
Dr. John Rodman, St. Jude Hospital
2:15 PM - Clinical Applications: Theophylline - Dr. Jelliffe
Setting the goals and planning the regimen: regular and
sustained release forms
2:45 PM - Clinical Applications: Prolonged Vancomycin Therapy
- Dr. Marcus Haug, Cleveland Clinic
A Deeper Tissue Compartment? Its Relation to Outcome?
3:15 PM - Break
3:30 PM - Clinical Applications: Analyzing Bacterial Growth and Kill
- Dr. Pascal Maire
4:00 PM - Clinical Applications: Zidovudine Chemotherapy
- Dr. Courtney Fletcher
4:00 PM - Clinical Applications: Gentamicin - Dr. Jelliffe
Setting the goals: once daily or what?
Modeling diffusion into vegetations or abscesses
Effect models - occupation of toxic binding sites
Modeling bacterial growth and kill, and post
- antibiotic effect.
4:50 PM - Once Daily Aminoglycoside Therapy - Pros and Cons
- Drs. Jelliffe, Forrest, and Rodman
Evaluating 80 q 8 versus 240 q 24 - 2 cases, 3 values of CCr
Serum AUC, and AUC in a peripheral effect compartment
Evaluating the relative benefit of nonlinear uptake
General Discussion
5:30 PM - Adjourn
PLEASE USE THE REGISTRATION FORM ON THE BACK OF THIS PAGE,
and also check our web address
Registration Form
I wish to register to attend the USC Symposium on "Model-Based,
Goal-Oriented Drug Therapy: New Advances in Population PK/PD Modeling,
Individualized Antibiotic Regimens, and 'Multiple Model' Drug Dosage"
on September 13th and 14th, 1996.
Registration________________________________________________
($275.00. For members of ASM, only $245.00)
Total: $________________
(Sorry - we cannot handle credit cards or purchase orders.
We can handle checks and foreign travelers checks in US dollars.)
Please make checks payable to the:
Laboratory of Applied Pharmacokinetics
Name of Registrant ______________________________ _
Institution________________________________________
Address__________________________________________ _
_______________________________________________ __
City, State, Zip_______________________________ _____
Country
Phone (____)________________Fax (____)_________________
Your Email address, please! ____________________________
I am___________am not____________a member of ASM.
Please return this form, with your check, directly to:
Roger W. Jelliffe, M.D.
Laboratory of Applied Pharmacokinetics
USC School of Medicine
CSC 134-B
2250 Alcazar Street
Los Angeles, CA 90033
Phone : (213) 342-1300, Fax : (213) 342-1302,
email: jelliffe at hsc.usc.edu
Note: Please register early! First come are first served. Registration
is limited to the spaces available. Cancellations must be made at least
10 days before the workshop in order to obtain a refund.
I would _____ would not _____ also like to receive information about
the USC software. I heard about this conference from______mailing
_____word of mouth _____electronic bulletin board_____other (please
specify)______________________
*************************************************************
We also have a page on the World Wide Web!! Its address is
http://www.usc.edu/hsc/lab_apk/
You might check it from time to time to see about new workshops
and software developments.
*************************************************************
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