Yeast genome analysis on a SGI Supercomputer - demonstration project.
schneider at embl-heidelberg.de
Fri Mar 1 01:19:00 EST 1996
GeneCrunch: See genome analysis on a supercomputer as it happens.
Watch the analysis of genome information live on the WWW, March 4-7, 1996.
In a joint demonstration project between Silicon Graphics and scientists
from the EMBL-Heidelberg/EMBL-EBI the GeneQuiz software system will analyze
more than 6000 protein sequences from the genome of yeast (Saccharomyces
cerevisiae) on a 64 processor SGI POWER CHALLENGEarray in just a few days.
The project will demonstrate large-scale genome sequence analysis on an
almost-complete set of yeast genes. The analysis will be repeated as soon
as the international collaborative effort of yeast researchers releases to
the public the complete genetic blueprint of yeast, scheduled for later
The results on the likely biological function of many new genes will
be of interest to biological researchers in both academia and industry.
The results will be published on two internet Web sites as the analysis
progresses, starting March 4th, 1996:
In addition to the biological results of the analysis, the sites will
also contain information describing the supercomputing and web technology
GeneQuiz is an automated system for large-scale genome sequence analysis.
It aims at adding value to biosequence information by predicting the
biological function of the corresponding genes. GeneQuiz accesses up-to-date
protein and DNA databases, derives information by sophisticated search and
analysis methods, and interprets any findings in terms of biological function
using expert rules.
It also predicts three-dimensional structures of protein molecules when
these can be inferred by homology . The predicted functions are made available
in hyperlinked WWW tables and the predicted coordinates of 3D structures in
Protein Data Bank format. GeneQuiz is a collaborative effort between the two
EMBL institutes and former EMBL scientists at CNB Madrid, MDC Berlin, and
SRI Meno Park.
The POWER CHALLENGEarray used for this project is located at the Silicon
Graphics European Supercomputing Technology Center in Cortaillod,
Switzerland. The POWER CHALLENGEarray consists of 4 POWER CHALLENGE nodes
each with 16 R8000 Processors linked together with the very fast HIPPI
Reinhard Schneider and Georg Casari
Biological Structures and Biocomputing program
European Bioinformatics Institute
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