PROCRUSTES: New Gene Recognition Software
ppevzner at hto-d.usc.edu
Tue Nov 26 14:50:02 EST 1996
Announcement: New version of Procrustes gene recognition software now
Version 3.01 beta of Procrustes is available as a WWW server:
or as an MS Windows application for the IBM PC. Procrustes uses
previously-sequenced genes to recognize new ones as described in
Gelfand, M.S., Mironov, A.A.,Pevzner, P.A.
"Gene recognition via spliced sequence alignment",
Proc. Natl. Acad. Sci. USA (1996), 93, 9061-9066
The distinctive features of Procrustes are:
- high reliability of predictions (up to 99%) in the presence of related
proteins as compared to 70-80% for most gene recognition programs;
- the possibility to analyze extremely long (up to 150,000 bp) sequences
with many (up to 20-30) exons;
- insensitivity to statistical inhomogeneity of genomes;
- the possibility to recognize very short exons;
- insensitivity to the presence of several genes in one sequence.
Version 3.01 beta of the WWW server includes:
- graphical output for exon-intron maps and alignment profiles;
- gene recognition by spliced alignment to several related proteins.
The next release will include:
- gene recognition in various species;
- error-tolerant gene recognition;
- assignment of confidence levels to recognition results;
- using EST sequences for gene recognition;
- gene recognition in incomplete sequences.
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