ANNOUNCE ProAnalyst -- new software for protein/peptide analysis

Alexy Eroshkin eroshkin at
Fri Sep 6 17:14:38 EST 1996

                ProAnalyst - PROTEIN ANALYST ver 1.02

        State Research Center of Virology and Biotechnology
             Koltsovo, Novosibirsk Region, 633159 Russia
              Vladimir Ivanisenko with Alexey Eroshkin

are pleased to announce the availability of an easy-to-use,
state-of-the-art MS-DOS application designed to solve traditional
and new tasks of protein science.

ProAnalyst FEATURES:

- inputs single and multiple protein sequences, activity/property/
  genotype data, protein 3D structures;

- finds sites influencing protein activity;

- finds relationships between protein sites' structural characteristics
  (hydrophobicity, amphipathicity, etc.) and protein activities;

- investigates differences between proteins divided by functional,
  evolutionary or other criteria (e.g. relates genotype to phenotype);

- investigates physico-chemical factors related with activity changes in
  a set of mutant proteins (including multiple physico-chemical factors);

- simulates protein-engineering experiments and predicts activity of
  mutant protein;

- searches motifs and patterns in combinatorial libraries (peptide and
  phage-displayed libraries);

- makes protein stereo pictures with sites highlighted;

- provides linear correlation analysis, multiple linear regression
  analysis, discriminant analysis, ANOVA (analysis of variance),
  alphabetical and classic profile/plot analysis;

- searches regions with high and low variability of physico-chemical

- calculates structure-activity correlation profile;

- performs cross and inter-group variability analysis based on
  several matrices of amino acid similarity;

- main part of methods are applicable to sequential as well as 3D sites;

- maps obtained results onto 3D structure;

- sorts sequences by activty, group number, motifs found;

- visualizes multiple alignments and protein 3D structures (stereo);

- has data converter from several protein sequence formats (FASTA,

- has data bases with 50 aligned protein families, more then 60 amino
  acid properties, HELP, Manual and examples with program applications.


- for chemists and biochemists making the investigations in the field of
  protein structure-function and structure-activity analysis;
- for protein engineers trying to improve some protein properties;
- for molecular biologists that need to get sense from multiple protein
  alignments and to analyze complicated combinatorial libraries;
- for geneticists studying phenotype-genotype correlations;
- for those who need color protein 3D pictures with sites highlighted;
- for students in any field of PROTEIN SCIENCE;
- for those who interested in comparative protein sequence analysis.


ProAnalyst is available from EBI software library:
(as self-extracted archive).

Current version works with up to 15 sequences. The length of sequences
must be less than or equal to 5000.

Comments, bug reports, suggestions for new features are welcome
and should be sent by e-mail to:
salex at (Vladimir Ivanisenko) or
eroshkin at (Alexey Eroshkin)

Dr. Alexey Eroshkin               Institute of Molecular Biology
E.mail: eroshkin at    State Research Center of Virology and
Tel: +7 (3832) - 647774           Biotechnology "Vector"
Fax: +7 (3832) - 328831           Koltsovo, Novosibirsk Region 633159

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